Analgesic Use for Pain Relief in Scorpion Sting

Adiyaman University Research Hospital106 enrolled

Overview

In scorpion stings, patients mostly apply with the complaint of pain. Emergency physicians need to relieve this pain quickly.

Aim: In this study, the analgesic efficacy of intravenous (IV) paracetamol, IV dexketoprofen trometamol and topical lidocaine will be compared in patients presenting with pain after scorpion sting. Methods: This study is a double-blind, randomized, placebo-controlled study conducted in a tertiary emergency department. Adult patients who applied to the study with no systemic findings after scorpion sting and especially with pain will be randomly assigned to one of 4 groups: IV paracetamol, IV dexketoprofen trometamol, topical lidocaine or placebo. In order to determine the intensity of pain, Visual Analog Pain Score (VAS) will be measured at the time of admission to the emergency department, at the 30th minute and at the 60th minute. Afterwards, the VAS score changes between the groups will be compared.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Enrollment

106

Conditions

Scorpion Stings

Interventions

paracetamolDRUG

1000 mg intravenous paracetamol in 100 mL normal saline

Dexketoprofen TrometamolDRUG

50 mg intravenous dexketoprofen Trometamol in 100 mL normal saline

Lidocaine topicalDRUG

Application of 5 gr of 5% topical lidocaine

Eligibility

Sex: ALLMin age: 18 YearsMax age: 100 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients aged 18 and over * Scorpion sting with pain * The diagnostic criteria of Grade 1 for Scorpion sting Exclusion Criteria: * Patients who denied to give informed consent * Taking analgesic treatment (ice application or drugs etc.) in the last 6 hours * Any symptoms and findings of systemic toxicity of scorpion sting * Pregnant women * Hemodynamically unstable patients * Known allergy to drugs of the study * Patients with renal disease * The cases that passed more than 6 hours after the bite

Locations (1)

Adiyaman University Research Hospital

Adıyaman, Central, Turkey (Türkiye)

Outcomes

Primary Outcomes

Change of the intensity of pain

Pain intense will be measured by 100 mm visual analog scale (Zero; no pain and 100 mm; the worst pain) after 30th and 60th minutes later after the study drug administered

Time frame: 30 minutes and 60 minutes after the study drug administered

Secondary Outcomes

Adverse events

60 minutes after the study drug administered

Time frame: 60 minutes after the study drug administered

need to rescue medication

60 minutes after the study drug administered

Time frame: 60 minutes after the study drug administered

Data from ClinicalTrials.gov

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