Lower third molar extraction is one of the most common treatments in oral surgery practice. It is a treatment with inherent complications such as postoperative pain, swelling or trismus. In order to minimize disconfort after extraction, analgesic and anti-inflammatory medication is prescribed. Recently, it is seen that circadian rhythm may play an important role on drugs metabolism, modulating its effect depending on the moment of administration. The aim of the study is to analyze if dosage modification of a Non Steroideal Anti-Inflammatory (ibuprofen) affects on postoperative pain, swelling and open mouth limitation comparing to the normal dosage.
A randomized crossover split-mouth clinical trial will be performed. After third molar extractions, patients will be prescribed ramdomly in one side wit the normal medication dosage while the contralateral side will be prescribed a modified dosage. Moreover, a blood sample will be obtained to analize the inflammatory profile.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
10
morning and afternoon
morning, afternoon and night
Fabian Perez Gonzalez
Madrid, Spain
Post operative Pain
Postoperative pain with visual analogue scale (VAS) from 0 (no pain) to 10 (maximum pain)
Time frame: From the day of the surgical procedure to the seventh-day
Swelling
Distance from tragus to pogonion in milimiters
Time frame: Baseline and post operatory (day 1, day 3, day 7)
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