The main goal of this trial is to learn more about the safety of repeated dosing with Lu AG09222. The trial doctors will keep track of the participant's overall health by asking them how they are and by analyzing blood and urine samples.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
30
Lu AG09222 will be administered per schedule specified in the arm description.
Placebo matching to Lu AG09222 will be administered per schedule specified in the arm description.
St Pancras Clinical Research
London, United Kingdom
Medicines Evaluation Unit
Manchester, United Kingdom
Number of Participants With Adverse Events
Time frame: Baseline (Day 1) up to Week 20
Area Under the Serum Concentration-Time Curve in the Last Dosing Interval (AUC0-τ) of Lu AG09222
Time frame: Up to 96 hours post last dose on Days 57 to 61; and on Days 64, 71, 78, and 84
Maximum Observed Concentration (Cmax) of Lu AG09222
Time frame: Predose on Days 1 and 57; up to 96 hours post last dose on Days 57 to 61; and on Days 64, 71, 78, and 84
Time to Maximum Observed Concentration (Tmax) of Lu AG09222
Time frame: Predose on Days 1 and 57; up to 96 hours post last dose on Days 57 to 61; and on Days 64, 71, 78, and 84
Apparent Elimination Half-Life of Lu AG09222
Time frame: Predose on Days 1 and 57; up to 96 hours post last dose on Days 57 to 61; and on Days 64, 71, 78, and 84
Change from Baseline to Week 8 in Wheal-Reaction Area at 20 and 120 Minutes After Allergen Challenge
Time frame: Baseline, Week 8
Change from Baseline to Week 8 in Flare-Reaction Area at 20 and 120 Minutes After Allergen Challenge
Time frame: Baseline, Week 8
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