This is a retrospective propensity score-matched analysis of a large institutional cohort of patients in order to compare long-term outcomes and clinicopathologic characteristics between patients treated with breast conserving surgery or mastectomy for breast cancer.
The aim of the study is to compare long-term outcomes and clinicopathologic characteristics between patients treated with breast conserving surgery + whole breast irradiation or mastectomy for breast cancer. Recent observations regarding long-term outcomes among patients with early-stage breast cancer who underwent breast-conserving surgery plus whole-breast irradiation or mastectomy are from a small number of registry-based studies. Therefore, these findings may overestimate differences in survival between the two groups, compared with randomized controlled trials conducted in the 1980s. This study performed a propensity score-matched analysis in a cohort of 9710 patients aged \<70 years who underwent breast conserving surgery + whole breast irradiation or mastectomy without external radiotherapy for a first primary breast cancer (pT1-2, N0-3a) at the European Institute of Oncology between 2000 and 2008. Patients were matched by propensity score.
Study Type
OBSERVATIONAL
Enrollment
9,710
Breast conserving surgery plus whole breast irradiation
Breast mastectomy
Cumulative incidence of ipsilateral breast tumor recurrence
Incidence of ipsilateral breast tumor recurrence in breast conserving surgery group compared to mastectomy group
Time frame: 10 years
Cumulative incidence of axillary lymph node recurrence
cumulative incidence of axillary lymph node recurrence in breast conserving surgery group compared to mastectomy group
Time frame: 10 years
Cumulative incidence of contralateral breast cancer
Cumulative incidence of contralateral breast cancer in breast conserving surgery group compared to mastectomy group
Time frame: 10 years
Rate of distant metastasis
Incidence of distant metastasis in breast conserving surgery group compared to mastectomy group
Time frame: 10 years
Cumulative incidence of breast cancer specific survival
Cumulative incidence of breast cancer specific survival in breast conserving surgery group compared to mastectomy group
Time frame: 10 years
Rate of overall survival
Incidence of survival in breast conserving surgery group compared to mastectomy group
Time frame: 10 years
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