Traditional aerobic training and muscle resistance ('strength') training have been shown to be effective for improving functional and health-related quality of life (HRQoL) outcomes in peripheral arterial disease (PAD). However, the transfer of the current resistance exercise modes proposed to other activities of daily living (ADLs) is questionable. Moderate intensity functional training (MIFT) has emerged with the aim of achieving cardiovascular and neuromuscular adaptations simultaneously with functional exercises typical of ADLs. The effect of MIFT in patients with PAD is not yet known. Our purpose is to verify the influence of the combination of intermittent treadmill walking exercise with MIFT compared with intermittent treadmill walking exercise on functional capacity, HRQoL, biochemical and hemodynamic parameters in patients with PAD.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
15
Subjects will perform a 12-week supervised exercise therapy program based on intermittent treadmill walking exercise (15-30 min.) and moderate intensity functional training (MIFT) (15 min.). In intermittent treadmill walking exercise, the speed and incline of treadmill will be adjusted that patients achieve moderate claudication pain in the time interval between 3 and 5 min. In MIFT, subjects must complete in 15 min. the highest number of repetitions / rounds possible (AMRAP) to a circuit composed of 6 global functional exercises from which they performed 10 repetitions with a rating of perceived exertion (RPE) of 5-7 on a 1 to 10 scale in each exercise.
Subjects will perform a 12-week supervised exercise therapy program based on intermittent treadmill walking exercise (30-45 min.). In intermittent treadmill walking exercise, the speed and incline of treadmill will be adjusted that patients achieve moderate claudication pain in the time interval between 3 and 5 min.
European University Miguel of Cervantes
Valladolid, Spain
Six-Minute Walk Test
Changes in maximum walking distance (MWD) and claudication onset distance (COD).
Time frame: 0 weeks, 6 weeks and 12 weeks.
Moderate intensity functional training Test
Changes in number of rounds/repetitions and total workload.
Time frame: 0 weeks, 6 weeks and 12 weeks.
Short Form-36 Health Survey (SF-36)
Changes in the eight domains of health status.
Time frame: 0 weeks, 6 weeks and 12 weeks.
Vascular Quality of Life Questionnaire-6 (VascuQol-6)
Changes in total punctuation of questionnaire.
Time frame: 0 weeks, 6 weeks and 12 weeks.
Biochemical analysis
Changes in complete lipid profile
Time frame: 0 weeks, 6 weeks and 12 weeks.
Biochemical analysis
Changes in lactate dehydrogenase
Time frame: 0 weeks, 6 weeks and 12 weeks.
Biochemical analysis
Changes in c-reactive protein
Time frame: 0 weeks, 6 weeks and 12 weeks.
Biochemical analysis
Changes in tumor necrosis factor alpha
Time frame: 0 weeks, 6 weeks and 12 weeks.
Biochemical analysis
Changes in serum apolipoproteins
Time frame: 0 weeks, 6 weeks and 12 weeks.
Biochemical analysis
Analysis of the complete oxidative profile
Time frame: 0 weeks, 6 weeks and 12 weeks.
Hemodynamic measurements
Changes in mean, systolic and diastolic blood pressure.
Time frame: 0 weeks, 6 weeks and 12 weeks.
Hemodynamic measurements
Changes in flow-mediated dilation of the brachial artery
Time frame: 0 weeks, 6 weeks and 12 weeks.
Hemodynamic measurements
Changes in ankle-brachial index
Time frame: 0 weeks, 6 weeks and 12 weeks.
Hemodynamic measurements
Changes in pulse wave velocity
Time frame: 0 weeks, 6 weeks and 12 weeks.
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