This study aims to investigate the microbiome of women with previously proven fertility who plan to become pregnant.
The women will be recruited at the time of removal of a copper or hormonal intrauterine device (IUD) or removal of a contraceptive implant at the barnmorskemottagningar (midwife clinics) in Stockholm's county in Sweden. A total of 500 women will be included in the study and will be followed until conception or up to the end of 1 year, whichever comes first. If conception occurs, the woman will be followed throughout pregnancy. Participant recruitment will take place over a period of two years.
Study Type
OBSERVATIONAL
Enrollment
500
Vaginal- and rectal sampling as a self-kit will be taken by the pat when ceasing the contraception at the midwife clinic when confirmed a clinical pregnancy and if a miscarriage occurs. If a miscarriage occurs additionally to the self-kit an endometrial biopsy will be taken.
Reproductive Medicine, Karolinska University Hospital
Stockholm, Huddinge, Sweden
NOT_YET_RECRUITINGReproduktionscentrum Akademiska sjukhuset
Uppsala, Sweden
RECRUITINGThe microbiome profile and metabolome associated with time to pregnancy, miscarriage, and live birth will be assessed.
Time frame: 2024
Microbiome profiles and metabolome related to obstetric outcomes
Time frame: 2024
The microbiome profile for women above age >38 and women below <38.
Time frame: 2024
The influence of BMI, medications and comorbidities on the microbiome profiles.
Time frame: 2024
Microbiome profile for those women who don't conceive within a year.
Time frame: 2024
The metabolome of the recognized microbiome for women with normal pregnancy outcomes
Time frame: 2024
The metabolome of the recognized microbiome for women who develop miscarriage or other pregnancy complications
Time frame: 2024
Sebastian Sebastian Brusell Gidlöf, PhD
CONTACT
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.