CBTpro: Scaling up CBT for Psychosis Using Simulated Patients and Spoken Language Technologies

University of Washington379 enrolled

Overview

The primary objective of this grant is to develop and evaluate an Artificial Intelligence-based clinical training tool--CBTpro--to support high-quality skills training in CBT for psychosis (CBTp). CBTpro will provide a rapid means of scaling and sustaining high-quality CBTp in routine care settings across the US.

This fast-track Small Business Technology Transfer (STTR) grant is a partnership between the University of Washington and private company LYSSN that includes the development and iterative testing of CBTpro, a Computerized Clinician Support Tool designed to teach behavioral health providers and students Cognitive Behavioral Therapy for psychosis (CBTp). CBTpro uses natural language processing to provide automated speech-to-text and machine learning to score trainee's responses to simulated patients with psychosis. Once technical reliability of the tool is achieved through iterative modifications based on usability and field trials, a randomized control trial will be conducted to assess CBTpro training vs. training as usual with N=100 providers / N=300 clients on clinician skills and client outcomes.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

379

Conditions

Psychosis Schizophrenia Schizo Affective Disorder Bipolar Disorder Depressive Disorder

Interventions

CBTproBEHAVIORAL

CBTpro is a novel spoken language technology tool to support high-quality skills training in CBT for psychosis.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 100 Years

Medical Language ↔ Plain English

Client Inclusion: Adults who speak English, meet with their provider who is participating in the study at least bi-weekly (2x a month), and do not plan to leave services in the next 6 months. Qualifying diagnoses for clients include: schizophrenia; schizoaffective disorder; schizophreniform disorder; delusional disorder; other specified schizophrenia spectrum and other psychotic disorder; unspecified schizophrenia spectrum or other psychotic disorder; bipolar disorder with psychotic features; major depressive disorder with psychotic features Exclusion criteria: Dx of psychosis secondary to substance intoxication

Locations (13)

South Central Health and Rehabilitation Programs

Los Angeles, California, United States

Psynergy

Morgan Hill, California, United States

Telecare

San Jose, California, United States

Outcomes

Primary Outcomes

Change in Green Paranoid Thoughts Scale (GPTS) Total Score

The Green Paranoid Thoughts Scale (GPTS) is a 32-item self-report questionnaire designed to assess paranoid ideation over the past month. It consists of two 16-item subscales: Part A: Ideas of Social Reference and Part B: Persecutory Ideas. Each item is rated on a 5-point Likert scale from 1 ("Not at all") to 5 ("Totally"). Subscale scores range from 16 to 80, and the total score ranges from 32 to 160, with higher scores indicating more severe paranoid thinking. A reduction in total or subscale scores indicates improvement in paranoid ideation.

Time frame: 0,3,6 months

Secondary Outcomes

Change in CHOICE-SF (Choice of Outcome in CBT for Psychosis- Short Form)

The CHOICE-SF is a 12-item self-report questionnaire designed to assess perceived progress toward recovery among individuals receiving cognitive behavioral therapy for psychosis (CBTp). Each item is rated on a scale from 0 ("Not at all") to 10 ("Extremely") with the exception of the final question which is open-entry. Total scores range from 0 to 110, with higher scores reflecting greater perceived progress in psychological recovery. An increase in the CHOICE-SF score indicates improvement in recovery; a decrease suggests reduced perceived progress.

Time frame: 0,3,6 months

Change in in Sheehan Disability Scale (SDS) Total Score

The Sheehan Disability Scale (SDS) is a 3-item self-report measure that assesses functional impairment in three domains: work/school, social life, and family life/home responsibilities. Each item is rated on an 11-point scale from 0 ("Not at all impaired") to 10 ("Extremely impaired"). The total score ranges from 0 to 30, with higher scores indicating greater functional impairment. A decrease in the total score reflects improved functioning.

Time frame: 0,3,6 months

Data from ClinicalTrials.gov

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