A Crossover Study Evaluating 3 Non-medicated Silicone IVRs

Inclusion Criteria: Females: * Aged 18-40 years old, inclusive, at Screening based on self-report * Sexually active, defined as having had penile-vaginal sex with a male partner at least four times per month (e.g. once a week), on average, in the three months before Screening * In a mutually monogamous relationship with the same male partner for at least 6 months prior to Screening, based on self-report * Male partner is eligible and consents to participation * Healthy based on medical history and physical exam at Screening * Currently using effective non-vaginal contraception for at least 3 months prior to screening, including injectable, oral contraception, contraceptive patch or sterilization (male or female) based on self-report * HIV-negative per test at Screening * Not pregnant per urine pregnancy test at Screening and Enrollment * Negative for chlamydia, gonorrhea, trichomoniasis or urinary tract infection (UTI) at screening * Symptomatic vulvovaginal candidiasis or bacterial vaginosis (BV) at Screening. (Participants who test positive at initial screening may be treated and rescreened after completing treatment). * Competent to provide written informed consent based on Investigator's assessment * Owns or has access to Smart phone per self-report * Agrees to not participate in any other clinical research for the duration of this trial Males: * Aged at least 18 years old at Screening based on self-report * Sexually active, defined as having had penile-vaginal sex with a female partner at least four times per month (e.g. once a week), on average, in the three months before Screening * In a mutually monogamous relationship with the same female partner for at least 6 months prior to Screening, based on self-report * Female partner is eligible and consents to participation * Healthy based on medical history and physical exam, including visual inspection of genitalia at Screening * HIV-negative per test at Screening * Negative for chlamydia, gonorrhea, trichomoniasis per tests at Screening (per local standard of care) at Screening * Competent to provide written informed consent based on investigator's assessment * Owns or has access to a Smart phone, per self-report * Agrees to not participate in any other clinical research for the duration of this trial Exclusion Criteria: Females: * Known or suspected allergy to silicone, as reported by participant * Positive pregnancy test at Screening or Enrollment based on urine hCG test * Positive for HIV per test at Screening * Presence of any clinically significant genital epithelial findings (e.g. abrasions, ulcerations, lacerations, or vesicles) suspicious of STIs at Screening or Enrollment * Positive chlamydia, gonorrhea, or trichomoniasis test at Screening (or Enrollment) * Current urinary complaints or diagnosed UTI at Screening (or Enrollment) * Presence of genital abnormalities via visual exam with speculum that would contraindicate IVR use at Screening or Enrollment * Significant uterine or vaginal prolapse, or urethral obstruction * Recurrent vaginitis (three or more episodes within the prior year) * Unexplained vaginal bleeding per self-report within the 3 months before Screening * Currently breastfeeding per self-report * Partial or complete hysterectomy per self-report * Gynecological surgery in the 6 months prior to Screening per self-report * Within 6 weeks post abortion or 6 months postpartum, per Self-report. * Using vaginal contraception (diaphragm, female condom, spermicide, IVR) * Abnormal finding on examination or a social or medical condition which, in the opinion of the investigator, would make participation in the study unsafe or would complicate interpretation of data. * Any other condition the clinician feels would jeopardize the health and wellbeing of the participant after assessing the participant's potential eligibility for the study * Unable to comply with study requirements, including but not limited to, attending all study visits and using the IVRs as directed. * Currently participating in any other clinical research trial involving investigational or marketed products Males: * Known or suspected allergy to silicone, as reported by * Positive test for HIV at Screening