The Coronavirus Pediatric Serological Study's aim is to provide a better insight of children's immune response after SARS-CoV-2 infection. Serological tests were conducted on blood samples taken 3 to 5 months after the children's viral infection. The study was performed in collaboration with the Institute of Medical Immunology, were antibody levels were measured and immunoglobulin subclasses profiles were studied.
The hospital laboratory provided us the list of children under 15 years old tested for SARS-CoV-2 in Saint-Pierre Hospital (Brussels) by PCR on nasopharyngeal swab between March 1 2020 and December 31 2020. The medical files of all children that were tested positive for SARS-CoV-2 were reviewed and clinical information was collected. For each positive child, the family was contacted by phone 3 months after the proven viral infection in order to ask permission to take a single blood test. Covid19 serologies were performed in the hospital laboratory, and blood samples were then sent to the Institute of Medical Immunology, were antibody levels and immunoglobulin subclasses were studied.
Study Type
OBSERVATIONAL
Enrollment
49
Blood sample taken 3 to 5 months after the infection
Saint-Pierre Hospital
Brussels, Belgium
SARS-CoV-2 antibody levels in asymptomatic patients
Measurement of SARS-CoV-2 IgG (total and subclasses), IgA (total and subclasses) and IgM levels in the sera of children who did not show any symptoms at the time of the viral infection
Time frame: 3 to 5 months after SARS-CoV-2 infection
SARS-CoV-2 antibody levels in mildly symptomatic patients
Measurement of SARS-CoV-2 IgG (total and subclasses), IgA (total and subclasses) and IgM levels in the sera of children presenting mild symptoms at the time of the viral infection
Time frame: 3 to 5 months after SARS-CoV-2 infection
SARS-CoV-2 antibody levels in hospitalized patients
Measurement of SARS-CoV-2 IgG (total and subclasses), IgA (total and subclasses) and IgM levels in the sera of children who required an hospitalisation at the time of the viral infection
Time frame: 3 to 5 months after SARS-CoV-2 infection
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