Chemotherapy treatments such as epirubicin-cyclophosphamid or paclitaxel lead to severe off-target side effects such as skeletal muscle deconditioning. To date, three different studies investigated skeletal muscle decontioning in breast cancer patients, through long term protocols including all chemotherapy cycle treatment, and highlighted both structural alterations and impaired cellular processes. However, no study is currently availbale on the acute effect of one single chemotherapy administration in breast cancer patients skeletal muscle tissue. Our study is therefore dedicated to the investigation of the acute effect of the first dose administration of both Epuribicin/cyclophosphamide and Paclitaxel chemotherapies on skeletal muscle of breast cancer patients.
Chemotherapy treatments such as epirubicin-cyclophosphamid or paclitaxel lead to severe off-target side effects such as skeletal muscle deconditioning. Resulting from a global perturbation of the muscle homeostasis, skeletal muscle is characterized by both structural and functional alterations that will translate into a decrease in muscle mass and/or force as well as an increase in muscle fatigability. These maladaptations result in a reduced quality of life and an increased treatment-related toxicity, ultimately leading to an increased mortality risk.To date, three different studies investigated skeletal muscle decontioning in breast cancer patients, through long term protocols including all chemotherapy cycle treatment, and highlighted both structural alterations and impaired cellular processes. However, no study is currently availbale on the acute effect of one single chemotherapy administration in breast cancer patients skeletal muscle tissue.Our study is therefore dedicated to the investigation of the acute effect of the first dose administration of both Epuribicin/cyclophosphamide and Paclitaxel chemotherapies on skeletal muscle of breast cancer patients. Our study will particularly explore cellular mechanisms of muscle decontioning, such as protein turnover, mitochondrial homeostasis and fatty infiltrations.
Study Type
OBSERVATIONAL
Enrollment
20
1 cycle of Epirubicin-cyclophosphamide
1 cycle of Paclitaxel
Institut de Cancerologie Strasbourg Europe
Strasbourg, France
Investigate the acute effect of chemotherapy administration on protein turnover cellular processes through vastus lateralis biopsies of breast cancer patients
Change From Baseline in Western Blots measurements of protein expression levels
Time frame: Before and 4 days after the chemotherapy
Investigate the acute effect of chemotherapy administration on structural alterations
Change From Baseline in Cross-Sectional Area (CSA) measurements
Time frame: Before and 4 days after the chemotherapy
Investigate the acute effect of chemotherapy administration on inflammation
Change From Baseline in Western Blots measurments of protein expression levels
Time frame: Before and 4 days after the chemotherapy
Investigate the acute effect of chemotherapy administration on mitochondrial homeostasis
Change From Baseline in Western Blot measurement of protein expression levels
Time frame: Before and 4 days after the chemotherapy
Investigate the acute effect of chemotherapy administration on fatty infiltrations
Change From Baseline in Western Blot measurement of protein expression levels
Time frame: Before and 4 days after the chemotherapy
Investigate the acute effect of chemotherapy administration on satellite cells
Change From Baseline in Western Blot measurement of protein expression levels
Time frame: Before and 4 days after the chemotherapy
.Comparison of the acute effect of Epirubicin-Cyclophosphamide versus Paclitaxel on the skeletal muscle mass
Change From Baseline in quantity of muscle mass measured by bioelectrical impedance analysis
Time frame: Before and 4 days after the chemotherapy
Comparison of the acute effect of Epirubicin-Cyclophosphamide versus Paclitaxel on the muscle force
Change From Baseline in the maximal isometric strength of the knee with force transducer
Time frame: Before and 4 days after the chemotherapy
Comparison of the acute effect of Epirubicin-Cyclophosphamide versus Paclitaxel on the muscle thickness
Change From Baseline in ultrasonography measurement
Time frame: Before and 4 days after the chemotherapy
Comparison of the acute effect of Epirubicin-Cyclophosphamide versus Paclitaxel on the muscle fibers angle of pennation
Change From Baseline in ultrasonography measurement
Time frame: Before and 4 days after the chemotherapy
Comparison of the acute effect of Epirubicin-Cyclophosphamide versus Paclitaxel on the muscle fibers fascicle length
Change From Baseline in ultrasonography measurement
Time frame: Before and 4 days after the chemotherapy
Comparison of the acute effect of Epirubicin-Cyclophosphamide versus Paclitaxel on the echogenecity
Change From Baseline in ultrasonography measurement
Time frame: Before and 4 days after the chemotherapy
Comparison of the acute effect of Epirubicin-Cyclophosphamide versus Paclitaxel on the quality of life
Change From Baseline in FACT-G auto-questionnaire measurement
Time frame: Before and 4 days after the chemotherapy
Comparison of the acute effect of Epirubicin-Cyclophosphamide versus Paclitaxel on the appetite loss
Change From Baseline in FAACT auto-questionnaire measurement
Time frame: Before and 4 days after the chemotherapy
Comparison of the acute effect of Epirubicin-Cyclophosphamide versus Paclitaxel on the physical activity level
Change From Baseline in GPAQ auto-questionnaire measurement
Time frame: Before and 4 days after the chemotherapy
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