Development and Validation of The Post-RT LARS Prediction Model (PORTLARS)

Sixth Affiliated Hospital, Sun Yat-sen University901 enrolled

Overview

Bowel dysfunction is common after a restorative rectal cancer resection. Neoadjuvant radiotherapy is an influential factor that impairs bowel function and quality of life. However, almost half patients who have received primary surgery with preoperative radiotherapy are able to restore a good or moderate bowel function in the long term. This multicenter observational study aims to identify the risk factors of severe bowel dysfunction after rectal cancer resection and neoadjuvant radiotherapy, in accordance with the LARS score, and to build a model that predicts long-term major LARS in the early stage of follow-up. Development and validation cohorts are enrolled from tertiary hospitals in China.

Study Type

OBSERVATIONAL

Enrollment

901

Conditions

Low Anterior Resection Syndrome Radiotherapy Rectal Cancer

Interventions

Questionnaire

Outcomes

Primary Outcomes

Area under the curve (AUC)

The AUC of PORTLARS in predicting major bowel dysfunction after restorative rectal cancer resection with neoadjuvant radiotherapy. The AUC is evaluated by calculating the area under curve of receiver operating characteristics which plots the proportion of true positive cases (sensitivity) against the proportion of false positive cases (1-specificity) based on various predictive probability threshold.