The purpose of this study is to investigate the ability of a wearable bioimpedance sensor to detect mild dehydration in healthy volunteers following the administration of Furosemide. In addition, the study will investigate changes in bioimpedance related to normal variation in tissue hydration (circadian changes, skin thickness, posture, and moderate activity). The study will also provide information on the durability of the sensor.
The subjects will use the patches for ten days. During the ten-day period, subjects are exposed to an intervention on day 2 or 3 while being monitored by health personnel: * Subjects are given a diuretic (Furosemide) and monitored for two hours without any intake. * The intervention is followed by intake of a rehydration solution (up to 1500 ml), containing glucose and electrolytes (Resorb Sport, Nestle S.A.).
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
OTHER
Masking
NONE
Enrollment
31
The subject is brought to mild dehydration (loss of approximately 1.5% of body weight) through intravenous injection of up to 40 ug Furosemide. The subject shall not ingest any fluid for the next 120 minutes.
The subject is rehydrated by oral intake of 1.5 liters Resorb Sport (Nestlé). The subject is monitored for 60 minutes following intake.
Oslo University Hospital
Oslo, Norway
Change in impedance following mild dehydration
Relative change in extracellular resistance measured by the investigational device following administration of Furosemide compared to control days
Time frame: 2 hours
Change in impedance following rehydration
Relative change in extracellular resistance measured by the investigational device following ingestion of 1500 ml Resorb (Nestlé)
Time frame: 1 hour
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