The COLIC Study: Colonization of the Infant Gut With B. Infantis EVC001 to Reduce Symptoms of Colic

Inclusion Criteria: * Infants with a diagnosis of infantile colic per Rome IV criteria and reported to cry/fuss for ≥ 3 hours/day, within a 24-hour period as determined by the 24-hour cry/fuss eDiary AND 24 hours of LENA vocalizations * Infants with a gestational period of ≥ 37 to 42 weeks * Infants between 14 and ≤ 42 days of life at the completion of screening/baseline tasks * Infants exclusively breastfed for at least 7 days immediately prior to enrollment and with mother's intent to continue feeding breast milk exclusively for the duration of the study * Mothers willing to use their own electronic device(s) to download and utilize all required study software (decentralized trial platform on a mobile device and the LENA device software on a Windows 10 or higher laptop or desktop that has at least 10 GB of free space and fast, reliable internet) * Mother is fluent in English Exclusion Criteria: * Infants born in multiple birth (i.e., twins, triplets, etc.) * Infants born with medical complications (i.e., neurological, cerebral palsy, confirmed food allergies) * Infants with current evidence of failure to thrive, fever, or illness * Infants with any GI tract abnormalities * Antibiotic, infant formula, solid food or iron supplement intake within 7 days prior to enrollment or mother's intent to feed non-study probiotics, prebiotics, infant formula, solid food or iron supplements to their infant at any time during the study * Infants who have consumed any probiotics since birth * Unwillingness to discontinue/avoid products used to treat IC (i.e., Simethicone, gripe water, colic drops, etc.) during the study. Note: consumption of IC products prior to the baseline period is NOT exclusionary * Maternal use of probiotics containing B. infantis during pregnancy, after the baby's birth and/or intent to use probiotics containing B. infantis at any time throughout the study * Maternal smoking or smoking within the home by any household member currently or during pregnancy * Mother following exclusionary diet due to her infant's colic (i.e., dairy elimination diet) * Any infant the Investigator deems to be ineligible for participation