Wroclaw Out-Of-Hospital Cardiac Arrest Registry

Wroclaw Medical University50 enrolled

Overview

The purpose of this study is to assess the efficacy of institutionalized care program of patients with out-of-hospital cardiac arrest.

Patients with out-of-hospital cardiac arrest included in the program will be treated with extracorporeal membrane oxygenation (ECMO) assisted cardiopulmonary resuscitation (CPR) with additional invasive procedures including coronary/pulmonary angiography and intervention. This type of treatment was not provided in institutionalized fashion in Wroclaw, Poland. Implementation of this program should improve survival in out-of-hospital cardiac arrest patients, which currently is less than 10%.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Out-Of-Hospital Cardiac Arrest

Interventions

ECMO assisted CPR in out-of-hospital cardiac arrestOTHER

Patients included in the registry will be transferred during LUCAS assisted CPR by the Wroclaw Emergency Medical Services to the Emergency Department of the Wroclaw University Hospital where blood gasses will be assessed. If two or more of the following: end-tidal carbon dioxide (CO2) \> 10 mm Hg, arterial partial pressure of oxygen (PaO2) \>50 mm Hg or oxygen saturation \>85%, and lactic acid \<18 mmol/L will be fulfilled patient will be further transferred to the Cardiac Catheterization Laboratory for V-A ECMO implantation followed by coronary/pulmonary artery angiography and intervention.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age \< 60 years * witnessed sudden cardiac arrest with immediate CPR * supposed cardiac cause of the event * ventricular fibrillation (VF) or pulseless ventricular tachycardia (VT) at first medical contact with 3 unsuccessful defibrillations (no ROSC) * CPR conducted with Lund University Cardiopulmonary Assist System (LUCAS™) * Estimated transfer time from the scene to the Emergency Department \< 30 minutes. * End tidal carbon dioxide (ETCO2) \> 10 mmHg Exclusion Criteria: * Total presumed time from 112 call to ECMO implantation longer than 60 minutes * Age \< 18 years old or \> 60 years old; * Non-shockable initial rhythm * Unavailability of the automated CPR device * Unavailability of the catheterisation laboratory * Severe concomitant illness with decreased life expectancy * Severe body injury * Severe active bleeding * Drowning * Terminal cancer

Locations (1)

Wroclaw University Hostpital

Wroclaw, Poland

RECRUITING

Outcomes

Primary Outcomes

mortality

all cause mortality

Time frame: 1 month

Secondary Outcomes

degree of disability

Modified Rankin Scale of 3 or lower

Time frame: 3 and 6 months after index event

Central Contacts

Wiktor Kuliczkowski, MD

CONTACT

+ 48 603 707 093 wiktor.kuliczkowski@umw.edu.pl

Data from ClinicalTrials.gov

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