Effect of Simvastatin on Sepsis and Febrile Neutropenia in Patients With Acute Lymphoblastic Leukemia

Inclusion Criteria: * Patients diagnosed with acute leukemia under treatment of a chemotherapy regimen * Stable performance status (ECOG: 0 or Karnofsky scale greater than 80%) at time of analysis and under chemotherapy regimen * Life expectancy greater than 48 hours after diagnosis * Oral route available * Have signed informed consent at the time of the study * Patients whose chemotherapy regimen is administered in a hospital rather than an outpatient manner Exclusion Criteria: * Patients with acute leukemias over 55 years of age and with impaired functional status at the time of diagnosis * Elevation of liver enzymes 3 times higher than the range established by the central laboratory * Persistent kidney involvement despite having adequate hydration * Pregnant patients * Patients with peripheral neuropathy considered severe or disabling grade * Patients with a history of psychiatric disorders or psychotic attacks * Individuals who do not have the oral route available, who are maintained with a nasogastric tube, or who require support for the diagnosis through parenteral nutrition * Patients undergoing peritoneal dialysis or hemodialysis treatment * Patients with leukemia associated with Down syndrome * Patients under low-intensity chemotherapy regimen or palliative regimen * Previous allergy to any statin component * Patients with a history of liver failure (Child-Pugh Stage B or C)