Influence of Simple Renal Cysts on Renal Function

Moscow State University of Medicine and Dentistry120 enrolled

Overview

This is a prospective, cohort, randomized clinical trial examining the effect of simple renal cysts on renal function.

This study is planned to include patients from S.I. Spasokukotskiy Citi Clinical Hospital with simple renal accidentally discovered cyst. The aim of the study is to evaluate the impact of simple renal cysts on renal function and explore the correlation between cyst's size, parenchymal atrophy, and renal function. After receiving the results, the analysis of the data obtained is carried out. 1. The symmetry of the function of both kidneys is analyzed 2. The relationship between the presence of a simple kidney cyst and a decrease in its function in comparison with a healthy kidney is analyzed. 3. The relationship between the maximum size of a kidney cyst and a decrease in its function in comparison with a healthy kidney is analyzed. 4. The relationship between the volume of the atrophied kidney parenchyma and a decrease in its function as compared with a healthy kidney is analyzed. 5. Correspondence of GFR indices obtained by scintigraphy and by calculation using the Schwartz formula

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

120

Conditions

Simple Renal Cyst Renal Function Disorder

Interventions

CT scan with contrastPROCEDURE

CT scan with contrast is necessary to determine the position of renal cysts, their location, and size (determine volume of atrophic parenchyma will be calculated).

NephroscintigraphyRADIATION

Nephroscintigraphy is necessary to determine the renal function

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Adult patients with simple kidney cyst Bosniak 1-2 * Normal blood creatinine values Exclusion Criteria: * Impossibility of performing CT with intravenous contrast enhancement. * Bosniak 3-4 * CKD * Bilateral cysts * Multiple renal cysts * Sinus cysts * Cysts with a max size less than 2 cm. * Single kidney * Chronic kidney disease and conditions associated with the potential decrease of kidney function * Glomerulonephritis * Chronic pyelonephritis * Amyloidosis * Diabetes * Autoimmune diseases * Urolithiasis * Kidney and upper urinary tract surgery * Anomalies of the kidneys and upper urinary tract with impaired outflow * Calcification of the renal arteries * Renal artery stenosis * Hypertensive nephropathy * Severe concomitant diseases requiring * Chemotherapy * Long-term (more than 10 days) antibiotic therapy in the last month * Long-term (more than 7 days) use of NSAIDs in the last month * Diagnostic and therapeutic manipulations accompanied by the introduction of X-ray contrast agents * Secondarily shriveled or non-functioning kidney * Kidney hypoplasia * Accessory kidney * a decrease in GFR below normal values for a kidney without a cyst (as determined by nephroscintigraphy)

Outcomes

Primary Outcomes

Renal function

Glomerular filtration rate (GFR, ml/min/1.73 m2) is a test used to check how well the kidneys are working. Specifically, it estimates how much blood passes through the glomeruli each minute. A GFR of 60 or higher is in the normal range. A GFR below 60 may mean kidney disease. A GFR of 15 or lower may mean kidney failure. The measurement of the glomerular filtration rate will be measured according to the results of the blood test and the results of nephroscintigraphy

Time frame: 1 month

Secondary Outcomes

Ratio of cyst size and volume of atrophic renal parenchyma

Computed tomography with contrast will be used to determine the position of renal cysts, their location, size and volume of atrophic parenchyma (cm2) are calculated

Time frame: 1 month

Central Contacts

Vigen Malkhasyan

CONTACT

+7(909) 644-16-88 vigenmalkhasyan@gmail.com

Sergey Sukhikh

CONTACT

+7(985) 307-74-50 docsukhikh@gmail.com

Data from ClinicalTrials.gov

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