Investigation of Low-intensity Focused Ultrasound Parameters

Virginia Polytechnic Institute and State University23 enrolled

Overview

This project examines the effects of different brain stimulation settings on muscle contractions. The investigators believe this study will help to better understand noninvasive brain stimulation techniques that may have the potential to aid in addiction, pain, and mental health issues. Participants undergo structural imaging, an fMRI and CT. These images are used to align the low-intensity focused ultrasound (LIFU) and transcranial magnetic stimulation (TMS) devices to temporarily change brain activity. Electromyography (EMG) will be used to record muscle contractions on the hand.

Study Type

INTERVENTIONAL

Allocation

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Development of LIFU for Clinical Purposes

Interventions

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Above criteria and must understand and speak English. Exclusion Criteria: * Contraindications to MRI, CT, or TMS 1. Claustrophobia 2. Pacemaker, aneurysm clips, neurostimulators, cochlear implants, metal in eyes, steel worker, or other implants. 3. Pregnancy 4. Active medical disorder or treatment with potential CNS effects 5. History of neurologic disorder 6. History of head injury resulting in loss of consciousness for \>10 minutes 7. History of alcohol or drug dependence 8. Failure to provide a social security number or tax ID number. This is required for tax purposes or payment cannot be processed.

Outcomes

Primary Outcomes

Waveforms

Changes in waveform peak will be observed per each variable application of LIFU

Time frame: Outcome measured throughout study participation - an average of 4 weeks per participant.