The purpose of this study is to evaluate the risk factors of recurrent preeclampsia and compare the short-term and long-term adverse outcomes of women and their offspring.
The investigators collected women delivered twice in a row in our hospital. The investigators divided these pregnant women into three groups. Women in the first group did not complicate preeclampsia at both deliveries; Women in the second group complicated preeclampsia at the first delivery or at the second delivery; women in the third group complicated preeclampsia at two deliveries. The investigators explore the risk factors of recurrent preeclampsia and measure blood pressure, blood lipids, thyroid function, glycosylated hemoglobin, ALT, AST, et al. in one year, three years, and five years after the second delivery.
Study Type
OBSERVATIONAL
Enrollment
1,000
Blood pressure will be monitored. BMI will be measured. Blood samples will be tested.
Department of Obstetrics and Gynecology, Key Laboratory for Major Obstetric Diseases of Guangdong Province, The Third Affiliated Hospital of Guangzhou Medical University
Guangzhou, China
blood pressure and hypertension of women
blood pressure ≥140/90 mmHg
Time frame: 1year after the second deliver
blood pressure and hypertension of women
blood pressure ≥140/90 mmHg
Time frame: 3 years after the second deliver
blood pressure and hypertension of women
blood pressure ≥140/90 mmHg
Time frame: 5 years after the second deliver
blood pressure and hypertension of offspring
blood pressure≥140/90 mmHg
Time frame: 1 year old
blood pressure and hypertension of offspring
blood pressure≥140/90 mmHg
Time frame: 3 years old
blood pressure and hypertension of offspring
blood pressure≥140/90 mmHg
Time frame: 5 years old
level of glycosylated hemoglobin in blood
women
Time frame: 1 year after the second deliver
level of glycosylated hemoglobin in blood
women
Time frame: 3 years after the second deliver
level of glycosylated hemoglobin in blood
women
Time frame: 5 years after the second deliver
level of cholesterol, LDL, HDL, VLDL-C in blood
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women
Time frame: 1 year after the second deliver
level of cholesterol, LDL, HDL, VLDL-C in blood
women
Time frame: 3 years after the second deliver
level of cholesterol, LDL, HDL, VLDL-C in blood
women
Time frame: 5 years after the second deliver
level of FT3,FT4, and hTSH in blood
women
Time frame: 1year after the second deliver
level of FT3,FT4, and hTSH in blood
women
Time frame: 3 years after the second deliver
level of FT3,FT4, and hTSH in blood
women
Time frame: 5 years after the second deliver
level of AST and ALT in blood
women
Time frame: 1year after the second deliver
level of AST and ALT in blood
women
Time frame: 3 years after the second deliver
level of AST and ALT in blood
women
Time frame: 5 years after the second deliver
BMI of offspring
weight(kg)/height(m)2
Time frame: 1 year old
BMI of offspring
weight(kg)/height(m)2
Time frame: 3 years old
BMI of offspring
weight(kg)/height(m)2
Time frame: 5 years old
level of insulin in blood
women
Time frame: 1year after the second deliver
level of insulin in blood
women
Time frame: 3 years after the second deliver
level of insulin in blood
women
Time frame: 5 years after the second deliver
level of fructosamine in blood
women
Time frame: 1year after the second deliver
level of fructosamine in blood
women
Time frame: 3 years after the second deliver
level of fructosamine in blood
women
Time frame: 5 years after the second deliver
level of AI37℃、AI4℃、PRA、ALD、AngII in blood
women
Time frame: 1 year after the second deliver
level of AI37℃、AI4℃、PRA、ALD、AngII in blood
women
Time frame: 3 years after the second deliver
level of AI37℃、AI4℃、PRA、ALD、AngII in blood
women
Time frame: 5 years after the second deliver