The purpose of the study is to characterize the pharmacokinetics of meropenem and piperacillin in ICU-patients at the time of the first dose administration and to contrast that with the same measurements obtained in the same patient 2-3 days later during the course of ICU treatment.
Study Type
OBSERVATIONAL
Enrollment
50
This is an observational study exploring the antibiotic plasma concentration profiles in ICU paitents after the first drug administration.
Karolinska University Hospital
Stockholm, Sweden
RECRUITINGVolume of distribution
Apparent volume of distribution calculated from repeated plasma concentrations measurements and pharmacokinetic modelling.
Time frame: For the first antibiotic administration and if possible for a second administration 48-72 hour later.
Plasma clearance
Plasma clearance calculated from repeated plasma concentrations measurements and pharmacokinetic modelling.
Time frame: For the first antibiotic administration and if possible for a second administration 48-72 hour later.
Plasma antibiotic concentrations at mid and end of dosing interval
Plasma antibiotic concentrations at mid and end of dosing interval
Time frame: For the first antibiotic administration and if possible for a second administration 48-72 hour later.
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