Dexmedetomidine for Prophylaxis Against PONV in Highly Susceptible Patients.

Cairo University180 enrolled

Overview

The study aims to compare between two bolus doses of dexmedetomidine in preventing PONV in highly susceptible patients.

Being A challenging complaint, many studies tried to find an effective preventive strategies for PONV. In this study protocol the investigators aim to compare between 0.5 mic/kg and 0.75 mic/kg bolus doses of dexmedetomidine when given toward the end of head and neck surgeries in highly susceptible patients with a controlled group receiving ondansetron. The primary outcome is the 1st 24 hours incidence of PONV Other outcomes include: * Time to 1st call for rescue antiemetic and the total amount of antiemetics * Number of PONV attacks * Post operative pain score with visual analogous scale (VAS) and time to 1st call for rescue analgesia * Sedation Score using Observer's Assessment of Alertness and sedation (OAA/S) * Patient satisfaction * Vital signs in the 1st 24 hours

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

SINGLE

Enrollment

180

Conditions

Postoperative Nausea and Vomiting Head and Neck Surgeries

Interventions

Dexmedetomidine Hydrochloride 0.5 mic/kg bolusDRUG

comparison between two bolus doses of dexmedetomidine with a placebo group

Dexmedetomidine Hydrochloride 0.75 mic/kg bolusDRUG

comparison between two bolus doses of dexmedetomidine with a conventional group receiving ondansetron.

PlaceboDRUG

equal volume of normal saline

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Two risk factors or more for PONV ( female, non-smoking, postoperative opioids, history of motion sickness or PONV ) * Head and neck surgeries in adults * ASA ( I , II ) Exclusion Criteria: * Patients on ( steroids , antiemetics or any drug caude emesis ) * Any active cardiac condition at the time of the surgery * Pregnancy

Locations (1)

Cairo University

Cairo, Egypt

Outcomes

Primary Outcomes

Incidence of PONV in the 1st 24 hours postoperatively

The overall incidence of nausea and vomiting in the 1st 24 hours following Head and neck surgeries.

Time frame: The first 24 hours ( every half an hour in the 1st 2 hours and then at 4,6,8,12 and 24 hours )