Bioequivalence Study of Vonoprazan From Topoprazan 20 mg Tablets (Hikma Pharma, Egypt) Versus Takecab 20 mg Tablets (Takeda Pharmaceutical Co. Ltd., Japan)

Inclusion Criteria: 1. Healthy male or female, age 18 to 55 years, inclusive. 2. Body weight within 15% of normal range according to the accepted normal values for body mass index (BMI). 3. Medical demographics without evidence of clinically significant deviation from normal medical condition, eg.: no history of heart, liver, kidney, gastrointestinal, nervous system, or metabolic abnormalities. 4. Results of clinical laboratory test are within the normal range or with a deviation that is not considered clinically significant by principal investigator. 5. Females should be on a suitable birth control method. 6. Fully informed subjects that consented to participate in the study. Exclusion Criteria: 1. Subjects with known allergy to the products tested. 2. Female subjects who were pregnant or nursing. 3. Acute infection within one week preceding first study drug administration. 4. History of drug or alcohol abuse. 5. Subject does not comply with the stated instruction of not taking any prescription or non-prescription drugs within two weeks before first study drug administration and until the end of the study. 6. Subject is on a special diet (for example subject is vegetarian). 7. Subject does not agree not to consume any beverages or foods containing methyl-xanthenes e.g. caffeine (coffee, tea, cola, chocolate etc.) 48 hours prior to the study administration of either study period until donating the last sample in each respective period. 8. Subject does not agree not to consume any beverages or foods containing grapefruit 7 days prior to first study drug administration until the end of the study. 9. Subject has a family history of severe diseases which have direct impact on the study. 10. Participation in a bioequivalence study or in a clinical study within the last 8 weeks before first study drug administration. 11. Subject intends to be hospitalized within 3 months after first study drug administration. 12. Subjects who has blood donated or lost more than 500 mL blood within 3 months prior to the study.