A Phase I Study to Evaluate XTR003 in Healthy Chinese Volunteers

Inclusion Criteria: 1. Men and women aged between 18-40 years 2. Normal electrocardiogram and echocardiography 3. Normal vital signs and physical examination 4. No any major illness 5. No clinically significant abnormalities in laboratory tests 6. No clinically significant anomalies in 12-lead ECG 7. Females of child bearing possibility should adopt effective medically approved contraceptive methods to prevent pregnancy for at least 6 months before the study and after the study 8. Voluntarily signed written consent from all subjects Exclusion Criteria: 1. Pregnancy or lactating woman 2. History of cardiovascular disease 3. History of any brain disease 4. History of coagulopathy 5. History of liver or gastrointestinal diseases or other factors that can interfere with drug absorption, distribution, excretion or metabolism 6. Past history of cancer 7. History of drug allergy 8. History of drug abuse or alcohol dependance 9. Any medications and treatments that may interfere with the test data or may cause serious side effects 10. Human immunodeficiency virus (HIV), hepatitis C or syphilis antibody test positive, hepatitis B surface antigen positive 11. Exposure to significant occupational radiation (e.g \>50 mvs/year) or exposure radioactive substances for therapeutic or research purposes over the past 10 years 12. Use of health products or medications (eg. coenzyme Q10, etc.) that have an effect on myocardial energy metabolism within 1 week 13. Hospital admission due to illness during the screening period