The Effect of Volatile Anesthesia and Total Intravenous Anesthesia on Shedding of the Endothelial Glycocalyx in Patients Undergoing Mastectomy and Breast Reconstruction Using Deep Inferior Epigastric Artery Perforator Free Flap

Inclusion Criteria: 1. Adult patients over 20 years old with ASA class I-III 2. Scheduled total mastectomy and deep inferior epigastric artery perforator flap breast reconstruction Exclusion Criteria: 1. emergency surgery 2. Bilateral deep inferior epigastric artery perforator flap breast reconstruction 3. patients unable to make their own decisions, illiterate, foreigners 4. Allergy / hypersensitivity to sevoflurane or propofol 5, Current or past history or thrombosis / thromboembolism 6\. patients who are taking oral contraceptives 7. Patients with renal insufficiency (eGFR 60 ml / min / 1.73 m 2 or less) 8. Patients receiving anticoagulants 9. pregnant and lactating women 10. Patients with history of psychiatric disease or neurological disease