Intrathecal Atropine Versus Intravenous Ondasetron in Post Operative Nausea Due to Intrathecal Morphine

Sohag University100 enrolled

Overview

To compare between intrathecal atropine versus preoperative administration of IV ondansetron in decreasing incidence of post operative nausea and vomiting related to intrathecal opioids in post operative period in perineal surgery as regard : efficacy and side effects .

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

100

Conditions

Perineal Surgery

Interventions

Ondansetron , atropine and bupivacaineDRUG

Patient received intrathecal hyperbaric bupivacaine ( 10 mg ) ( 2 ml 0.5% ) with morphine 250mic and atropine sulphate 100 micwith total volume = 2.5 ml . Patient received intrathecal hyperbaric bupivacaine ( 10 mg ) ( 2 ml 0.5% with 0.5 ml normal saline with morphine 250 mic ) with total volume = 2.5 ml with giving 4 mg IV ondansetron before anesthesia ( patients with body weight more than 80 Kg may need additional 4 mg IV ) .

Eligibility

Sex: ALLMin age: 18 YearsMax age: 45 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Age between ( 18 - 45 ) years. * Body mass index between ( 18.5 - 35 ) * patients undergoing perineal surgery as anal fissure , piles and rectocele * patients receiving bupivacaine ( 20 mg / 4 ml ) as spinal anesthesia * Patinets with physical status 1 or 2 according to ASA classification Exclusion Criteria: * Patient refusal . * Any contraindication of neuraxial block as : coagulopathy , skin infection at injection site or bacteremia , hypovolemia and shock , history of allergy to L.A , sever aortic stenosis or mitral stenosis ……… etc * Patients with physical status other than 1 and 2 according to ASA classification * Those with history of nausea and vomiting , also those who received anti emetic drugs in last 2 hours of operation . * Allergy to any of the drug included in this study .

Locations (1)

Sohag University Hospital

Sohag, Egypt

Outcomes

Primary Outcomes

frequency of attacks of postoperative nausea and vomiting

Intrathecal atropine versus preoperative intravenous ondasetron for prevention of postoperative nausea and vomiting due to intrathecal morphine

Time frame: 6-9 months

Central Contacts

shehab m mohamed, resident

CONTACT

01147223196 shehabmahmoud@med.sohag.edu.eg

elhadad a mousa, professor

CONTACT

Data from ClinicalTrials.gov

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