Effects of Japanese Red Wines on Vascular Function in Adult Men

Inclusion Criteria: * Male: 50-70 years old * Subject is willing and able to comply with the study protocols. * Subject is willing to participate in all study procedures * BMI 18.5 - 40 kg/m2 * Weight ≥ 110 pounds * Prescription medication if on a 6-month self-reported stable dose * Regularly consume alcoholic beverages (2 drinks/week to 2 drinks/day) * Non-smokers * One standard drink of alcoholic beverages is defined as follow: 12-ounces of beer (5% alcohol content) (\~1 regular bottle). 8-ounces of malt liquor (7% alcohol content) (\~1 regular bottle). 5-ounces of wine (12% alcohol content) (\~½ glass) 1.5-ounces of 80-proof (40% alcohol content) distilled spirits or liquor (e.g., gin, rum, vodka, whiskey) (\~ 1 shot) Exclusion Criteria: * BMI ≥ 40 kg/m2 * Daily use of aspirin or NSAIDs * Dislike or allergic to any food, especially wine, grape, and alcohol * Vegan, Vegetarians, food faddists, or those consuming a non-traditional diet * Alcohol consumption \< 2 drinks/week (i.e. 1 bottle of beer, ½ glass of wine, and 1 shot of hard liquor) * Alcohol consumption \> 2 drinks/ day * Fruit consumption ≥ 2 cups/day * Vegetable consumption ≥ 3 cups/day * Fatty Fish ≥ 3 times/week * Coffee/tea ≥ 3 cups/day * Dark chocolate ≥ 3 oz/day * Self-reported restriction of physical activity due to a chronic health condition * Self-reported chronic/routine high intensity exercise * Self-reported diabetes * Blood pressure ≥ 140/90 mm Hg * Self-reported renal or liver disease * Self-reported heart disease, which includes cardiovascular events and Stroke * Self-reported Cushing's syndrome * Self-reported chronic/routine high-intensity exercise * Inability to properly place or wear the PAT probes or abnormal measurements on pre-screening PAT * Abnormal Liver or Chemistry panels (laboratory values outside the reference range) if determined to be clinically significant by the study physician. * Self-reported cancer within the past 5 years * Self-reported malabsorption * Use of multi-vitamin and minerals other than a general formula of vitamins and minerals that meet the recommended dietary allowance (RDA) * Not willing to stop any supplement use, including herbal, plant or botanical, fish oil, oil supplements a month prior to study enrollment. * Indications of substance or alcohol abuse within the last 3 years * Current enrollee in a clinical research study. * Reactive hyperemia index (RHI) value ≥ 2.8 (measured by PAT at the first study visit) * Raynaud's disease, history of bleeding disorder and/or abnormal bleeding, and history of gastrointestinal ulceration and/or bleeding * Under current medical supervision * 1 ug/ml and 3 ug/ml collagen screening maximal platelet aggregatory response of \< 65%. * Platelet number or mean platelet values that are outside of the normal reference range as indicated on a complete blood cell count report from the University of California Davis Medical Center * Current diagnosis of anemia; or a screening hemoglobin and hematocrit that is less than the normal reference range.Individuals with blood clotting or platelet defect disorders The following special populations will be excluded: * Individuals who are not yet adults (infants, children, teenagers) * Pregnant women * Prisoners