The purpose of this study is to assess which blood pressure medication (intravenous labetalol or oral nifedipine) works better in treating severely elevated blood pressure in women who have just delivered a baby.
Hypertensive emergencies cause significant maternal morbidity and mortality in the postpartum period. In order to reduced these risks, the recommendation is to treat women with severe range blood pressure with either intravenous labetalol or oral nifedipine; it is unclear which medication is superior. The objective of this study is to prospectively enroll women who have hypertensive emergencies in the postpartum period; women will be randomized in a 1:1 fashion and treated with one of the two antihypertensives to see which one works better.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
104
Intravenous labetalol, a short acting ant-hypertensive
Oral nifedipine, a short acting ant-hypertensive
Columbia University Irving Medical Center
New York, New York, United States
RECRUITINGAverage Time to Initial Blood Pressure Control (minutes)
The primary outcome will be time (minutes) interval required to achieve the therapeutic BP goal of \<160 mmHg systolic and \<110 mmHg diastolic.
Time frame: Up to 48 hours
Average Number of Recurrence of Severe Blood Pressure
The number of times a patient has recurrence of severe hypertensive necessitating treatment with an antihypertensive.
Time frame: Up to 48 hours
Total Number of Participants Who Need for Second Antihypertensive Agent
The need to use a second (alternative) antihypertensive medication.
Time frame: Up to 48 hours
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