This study aims at identifying the neurohormonal biomarkers that characterize individuals at risk of greater metabolic adaptation to weight loss, a disproportionate decline in resting metabolic rate during and after weight loss.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
OTHER
Masking
NONE
Enrollment
60
participants will be enrolled in a medical weight loss program and will be given a 6 month subscription to a calorie-reduced meal replacement program, in addition to lifestyle advice.
Medical College of Wisconsin
Milwaukee, Wisconsin, United States
change in measured and predicted resting metabolic rate during and after weight loss
resting metabolic rate will be measured by indirect calorimetry every 2 months for 6 months, then every 6 months for an additional 12 month. Predicted resting metabolic rate will be calculated with a mathematical formula at the same time points
Time frame: 18 months
change in circulating leptin during and after weight loss
blood will be assayed for this hormone every 2 months for 6 months, then every 6 months for an additional 12 months
Time frame: 18 months
change in circulating thyroid hormones during and after weight loss
blood will be assayed for this hormone every 2 months for 6 months, then every 6 months for an additional 12 months
Time frame: 18 months
change in circulating GLP-1 during and after weight loss
blood will be assayed for this hormone every 2 months for 6 months, then every 6 months for an additional 12 months
Time frame: 18 months
change in circulating PYY during and after weight loss
blood will be assayed for this hormone every 2 months for 6 months, then every 6 months for an additional 12 months
Time frame: 18 months
change in circulating AgRP during and after weight loss
blood will be assayed for this hormone every 2 months for 6 months, then every 6 months for an additional 12 months
Time frame: 18 months
change in 24h urine catecholamines during and after weight loss
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urine will be assayed for these hormones every 2 months for 6 months, then every 6 months for an additional 12 months
Time frame: 18 months
change in heart rate variability during and after weight loss
blood will be assayed for this hormone every 2 months for 6 months, then every 6 months for an additional 12 months
Time frame: 18 months