The investigators will compare patients with and without infective ndocarditis undergoing valve surgery and evaluate factors that may help optimise perioperative care of these high-risk patients.
The aim of this study is to examine the differences between patients with and without endocarditis who undergo cardiothoracic (valve) surgery. In addition, the investigators will look at the differences between endocarditis patients who undergo surgery, and those who are treated conservatively. The investigators will look at incidence and degree of perioperative coagulation abnormalities, as well as transfusion and coagulation factor requirements, heparin resistance, bleeding scores, predictive endocarditis mortality scores, vasopressor-inotrope scores, and relate these where possible to the pathogen causing IE. The investigators will also look at perioperative complications, in particular, thromboembolic events and mortality at 30 and 90 days, and at 1 year. These outcomes may help optimise perioperative care for high-risk endocarditis patients, and in particular those undergoing valve surgery.
Study Type
OBSERVATIONAL
Enrollment
3,000
Patients with infective endocarditis who do and do not undergo valve surgery compared with patientswithout endocarditis, who are operated on with similar valve surgery
Academic Medical Center
Amsterdam, North Holland, Netherlands
RECRUITINGThromboembolic complications
Any thromboembolic complications occuring between surgery and 1 year post operatively (incidence, class and severity)
Time frame: up to 1 year
Incidence of perioperative coagulation abnormalities
How often perioperative coagulation abnormalities, measured by classical laboratory values and rotational thromboelastometry are seen from diagnosis to 24 hours post-surgery
Time frame: First 24 hours after surgery
Differences in incidence of pathogens and the relation with disease severity
To evaluate the effect of different pathogens (evaluated by laboratory results) on the clinical status
Time frame: Up to 30 days
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