Dravet syndrome is a rare form of severe epilepsy that begins in the first year of life and is associated with frequent and/or prolonged seizures. Individuals with Dravet Syndrome often experience a range of comorbidities, including behavioral and developmental delays, movement and balance issues, sleep difficulties, chronic infections, and growth and nutritional issues. Patients with Dravet syndrome are at high risk of death due to SUDEP (Sudden Unexpected Death in Epilepsy), prolonged seizures, seizure-related accidents, and infections. Due to the severity of this condition, parents of children with Dravet syndrome are typically highly involved in their child's 24-hour care and this has a considerable impact on family life. Recent studies have highlighted the profound impact that such caregiving has on physical health, mental health, social function and financial resources. In particular, caregivers report high levels of stress and anxiety, fatigue, depression and social isolation. However, there is currently a lack of effective interventions to reduce the negative impact of caregiving on caregivers. The aim of this study is to prospectively study carers of individuals with Dravet syndrome to identify pharmacological and psychological factors that are associated with increased or decreased vulnerability to stress, depression and anxiety. Using a naturalistic, observational design the investigators will assess a cohort of Dravet Syndrome carers every six months for 3 years in order to further characterise trajectories of caregiver burden and the factors that influence this, including factors related to the person with Dravet syndrome (e.g. age, seizure frequency/severity, treatment/medications, comorbidities) and factors related to the carer and family environment (e.g. social engagement/isolation, fatigue, finances, relationships). The investigators will use both standardized questionnaires and a neurocognitive task (Facial Expression Recognition Task) to assess vulnerability to anxiety and depression. The study will be conducted online.
Study Type
OBSERVATIONAL
Anxiety and depression scores on the Hospital Anxiety and Depression Scale (HADS)
Higher scores indicate higher symptom levels (worse outcome)
Time frame: Follow up at three years
Anxiety and depression scores on the Hospital Anxiety and Depression Scale (HADS)
Higher scores indicate higher symptom levels (worse outcome)
Time frame: Follow up at two years
Anxiety and depression scores on the Hospital Anxiety and Depression Scale (HADS)
Higher scores indicate higher symptom levels (worse outcome)
Time frame: Follow up at one year
Caregiver stress scores on the UW Caregiver Stress Scale
Higher scores indicate higher symptom levels (worse outcome)
Time frame: Follow up at three years
Caregiver stress scores on the UW Caregiver Stress Scale
Higher scores indicate higher symptom levels (worse outcome)
Time frame: Follow up at two years
Caregiver stress scores on the UW Caregiver Stress Scale
Higher scores indicate higher symptom levels (worse outcome)
Time frame: Follow up at one year
Emotional processing biases on the Facial Expression Recognition Task (FERT)
Time frame: Follow up at three years
Emotional processing biases on the Facial Expression Recognition Task (FERT)
Time frame: Follow up at two years
Emotional processing biases on the Facial Expression Recognition Task (FERT)
Time frame: Follow up at one year
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.