Long-term Consequences of Neuroimaging and Perceived Cognitive Dysfunction in oPRES

Dunjin Chen500 enrolled

Overview

The purpose of this study is to explore the long-term consequences of neuroimaging and perceived cognitive dysfunction in obstetrics posterior reversible encephalopathy syndrome.

This is a prospective study. The investigators divided the PE or E patients into two groups, namely PRES group and non-PRES group, according to diagnostic criteria . The general information（demographic data，blood pressure.etc.）and blood sample will be collected. Additionally,all patients receive neuroimaging examination（DTI,ASL,3D-TMI.etc.）and neuro-cognitive test（MMSE,MOCA,CFQ, etc.） to assess the cerebral white matter lesions and cognitive changes.

Study Type

OBSERVATIONAL

Enrollment

500

Conditions

Neuroimaging Cognitive Dysfunction Posterior Reversible Encephalopathy Syndrome

Interventions

neuroimaging examination,neuro-cognitive test,blood pressure,blood sampleBIOLOGICAL

neuroimaging will be perform,neuro-cognitive will be tested,blood pressure will be monitored,blood samples will be tested

Eligibility

Sex: FEMALEMin age: 15 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. patients were diagnosed of PE or E 2. patients received cranial image examination 3. patients consent to participate Exclusion Criteria: 1. patients combined other neurological diseases 2. patients combined mental illness

Locations (1)

Department of Obstetrics and Gynecology, Key Laboratory for Major Obstetric Diseases of Guangdong Province, The Third Affiliated Hospital of Guangzhou Medical University

Guangzhou, China

Outcomes

Primary Outcomes

neuroimaging examination

the degree of white matter lesions(0,normal; 1, limited cortical or subcortical white matter oedema; 2, white matter oedema \> cortical oedema, white matter oedema extending into deep white matter; 3, white matter oedema \> cortex oedema, oedema extending to the ventricular surface; 4, the involved regions substantially extend to the ventricular surface and are almost completely conﬂuent; 5, involved regions are fully conﬂuent and continuous, ventricular deformity due to the oedema).The value of fractional anisotropy(FA) in PRES group may higher than non- PRES group, and mean diffusivity (MD) in PRES group may lower than non- PRES group.