Proton and Carbon Ion Radiotherapy for Cervical Cancer

Shanghai Proton and Heavy Ion Center16 enrolled

Overview

The aim of this study is to evaluate the toxicity and tolerance of proton and carbon ion radiotherapy (PCRT) for cervical cancer.

To retrospectively analyze cervical cancer patients received radical proton and carbon radiotherapy in our center. The acute and late toxicities, overall survival (OS), local control rate (LC), progression-free survival (PFS) and distant metastasis-free survival (DMFS) were analyzed.

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Cervical Cancer

Interventions

proton and carbon ion radiotherapyRADIATION

proton and carbon ion radiotherapy

Eligibility

Sex: FEMALEMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. . histologically diagnosis of squamous cell carcinoma of the cervix; 2. . International Federation of Gynecology and Obstetrics (FIGO) stage (2014) IB2 - IIIB, without rectum invasion; or FIGO stage IA - IB1, who refused surgery or were contraindication for surgery due to comorbidity diseases; 3. . received proton and carbon ion radiotherapy (PCRT) with or without chemotherapy for curative intention; 4. . Follow-up data available. Exclusion Criteria: 1. a previous history of other malignancy; 2. squamous cell carcinoma of the cervix patients who had received surgery; 3. rectum was invaded.

Outcomes

Primary Outcomes

Number of participants with treatment-related adverse events as assessed by CTCAE v4.0

Time frame: through study completion, an average of 1 year

Secondary Outcomes

overall survival rate

Time frame: 3 years

local control rate

Time frame: 3 years

progression-free survival

Time frame: 3 years

distant metastasis-free survival

Time frame: 3 years

Data from ClinicalTrials.gov

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