59 medically healthy patients, who are scheduled for third molar extraction surgery and give informed consent for the trial, are operated using a split-mouth technique. One group of patients will be assigned to the test group (Amoxilan) for the first surgery and to the control group (placebo) for the second surgery, and vice versa, according to randomisation. Patients receive 8 capsules Amoxilan or placebo (according to randomisation) perioperatively, and 6 capsules Amoxilan/placebo per day for 3 days postoperativeley.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Enrollment
59
Patients receive 8 capsules Amoxilan perioperatively and for the next 3 days 6 capsules per day
Patients receive 8 capsules placebo perioperatively and for the next 3 days 6 capsules per day
Medizinische Universität Graz, Klin. Abteilung für Orale Chirurgie und Kieferorthopädie
Graz, Austria
Mouth opening restrictions: Change of interincisal distance
Interincisal distance, with maximum mouth opening, is measured with a ruler.
Time frame: preoperatively as well as on the 1st and 7th postoperative day
Change of swelling
Swelling in the cheek area will be determined using a tape measure and 3D photographs.
Time frame: preoperatively as well as on the 1st and 7th postoperative day
Change of Visual Analogue Scale (VAS): Bleeding
Patients indicate bleeding symptoms on a VAS scale, ranging from 0-10, whereas higher values indicate a worse outcome
Time frame: day of surgery, and on day 1, 2, 3, 4, 5, 6, 7 after surgery
Change of Visual Analogue Scale (VAS): Swelling
Patients indicate swelling on a VAS scale, ranging from 0-10, whereas higher values indicate a worse outcome
Time frame: day of surgery, and on day 1, 2, 3, 4, 5, 6, 7 after surgery
Change of Visual Analogue Scale (VAS): Pain
Patients indicate pain on a VAS scale, ranging from 0-10, whereas higher values indicate a worse outcome
Time frame: day of surgery, and on day 1, 2, 3, 4, 5, 6, 7 after surgery
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