2015 European Society of Cardiology Guidelines have proposed the combination of Ampicillin and Cloxacillin for initial empirical treatment of infective endocarditis in acute severely ill patients (before pathogen identification). Yet this combination has never been studied in clinical trials. High dose penicillin treatments are associated with a risk of nephrotoxicity. The investigator's primary purpose is to describe patients treated with high dose Amoxicillin and Cloxacillin combination and to evaluate its renal tolerance.
Study Type
OBSERVATIONAL
Enrollment
50
Service de maladies infectieuses et tropicales - Hôpitaux Universitaires de Strasbourg
Strasbourg, France
RECRUITINGDescription of patients treated with dual IV therapy combining cloxacillin and amoxicillin in high doses at Strasbourg University Hospital
Time frame: Files analysed retrospectively from January 01, 2016 to December 31, 2020 will be examined]
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