The purpose of this study is to determine the features of clinical imaging, disease severity and pregnancy outcomes in posterior reversible encephalopathy syndrome with preeclampsia or eclampsia.
The investigators retrospectively collected data (General information, clinical data, biochemical indicators, imaging features, and pregnancy outcome) from pregnant woman diagnosed with PRES with preeclampsia or eclampsia to analyze features of clinical imaging, disease severity and pregnancy outcomes during 2012 to 2021.Then, the investigators grouped all the patients into early onset group and late onset PE group according to gestational weeks to analyze differences of clinical imaging. Finally, the investigators grouped all the patients into good pregnancy outcomes group and poor pregnancy outcomes group according to diagnostic criteria, including the incidence of stillbirth and premature birth, to analyze differences of clinical imaging .
Study Type
OBSERVATIONAL
Enrollment
354
patients diagnosed with posterior reversible encephalopathy syndrome with preeclampsia or eclampsia
Department of Obstetrics and Gynecology, Key Laboratory for Major Obstetric Diseases of Guangdong Province, The Third Affiliated Hospital of Guangzhou Medical University
Guangzhou, China
features of clinical imaging
The imaging features were described by their location including frontal, parietal, occipital, temporal, cerebellum, basal ganglia, brain stem, deep white matter and callosum, and 1 point was recorded for each location involved.
Time frame: Cranial Imaging was examined immediately at the onset of symptoms, such as s headaches, visual changes, seizures, consciousness impairment, mental disorders, and focal neurological deficits.
blood pressure(BP)
hypertension：≥140/90mmHg
Time frame: The BP of patients was obtained immediately at the onset of symptoms.
biochemical parameters
The PRES patients may have a lower level of serum albumin (﹤35g/L) ,and have a higher level of lactic dehydrogenase (﹥380U/L).
Time frame: Biochemical indicators were collected within 1 week of the hospital stay.
pregnancy outcomes
The rates of stillbirth and premature birth (gestation less than 37 weeks) in PRES patients.
Time frame: The pregnancy outcomes will record immediately when the patients deliver.
pregnancy outcomes
The PRES patients may have longer time of hospitalization.
Time frame: From day of admission until the day of discharge or date of death from any cause,whichever came first,assessed up to 1 year.
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