The purpose of the study is to evaluate the efficacy and safety of avatrombopag for the promotion of platelet engraftment after Allo-HSCT.
Patients with thrombocytopenia (PLT\<20×10\^9/L) after allogenic hematopoietic stem cell transplantation (Allo-HSCT) who meet Eligibility Criteria were assigned into the avatrombopag group for 4 weeks' treatment.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
20
Avatrombopag administered at the described frequency to achieve a target platelet count
Supportive care other than TPO-RAs or recombinant human thrombopoietin.
The first affiliated hospital of Soochow University
Suzhou, Jiangsu, China
RECRUITINGPercentage of participants whose PLT reaches ≥ 20*10^9/L without the need for PLT transfusion.
Accumulated platelet engraftment ratio
Time frame: up to 4 weeks
Percentage of participants whose PLT reaches ≥ 50*10^9/L without the need for PLT transfusion.
Accumulated complete platelet engraftment ratio
Time frame: up to 4 weeks
The time to achieve PLT ≥ 20*10^9/L without the need of PLT transfusion for consecutive 7 days (Defined as the first day when PLT ≥ 20×10^9/L without relying on platelet transfusion for 7 consecutive days )
time duration of platelet engraftment
Time frame: up to 4 weeks
Volume of PLT transfusion
Volume of PLT transfusion
Time frame: up to 4 weeks
Hematopoietic reconstruction condition
absolute neutrophils, hemoglobin
Time frame: up to 4 weeks
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