RALOX as Second Line Treatment for Advanced Malignant Biliary System Tumor

Inclusion Criteria 1. 18-75 years old. 2. Patients with unresectable advanced advanced Gallbladder carcinoma or Cholangiocarcinoma confirmed by histology or cytology. 3. First-line chemotherapy failure (toxic side effects can not be tolerated, disease progression during treatment or relapse after treatment) ;Or the disease recurred within 6 months after completion of adjuvant chemotherapy. 4. At least one measurable lesion according to RECIST1.1 criteria. 5. ECOG: 0 \~ 1. 6. Life expectancy ≥ 12 Weeks. 7. The major organs were functioning normally, and the laboratory examination results within 1 week met the following conditions before enrollment:①Absolute neutrophil count (ANC)≥1.5×109/L ②Platelet count（PLT）≥80.0 × 109/L ③Hemoglobin concentration（HB） ≥90g/L④ Total bilirubin（TB）≤1.5×ULN ⑤ Serum creatinine （Cr）≤l.5×ULN ，Endogenous creatinine clearance \>60ml/min（Cockcroft-Gault Formula ）⑥Aspartate aminotransferase (AST), Alanine aminotransferase (ALT), Alkaline phosphatase(AP): ≤3 ×ULN (≤5 ×ULN for metastases to liver). 8. Sign the informed consent voluntarily. Exclusion Criteria 1. Allergic to any research drug and its excipients. 2. Prior use of raltitrexed or oxaliplatin. 3. History of other malignancies, except cured Basal cell or squamous Cell Carcinoma of the skin and carcinoma in situ of the cervix. 4. There is a history of brain metastases. 5. History of psychotropic drug abuse and cannot quit or has a mental disorder. 6. Uncontrolled chronic infectious and non-infectious diseases. 7. Active or clinically poorly controlled severe infection 8. Other conditions that the researchers think should be ruled out.