Blood stream infection (BSI) during febrile neutropenia (FN) is a lethal complication, while confirmed diagnosis via blood culture is usually with low sensitivity and time delay. The new technique of metagenome next generation sequencing (mNGS) has the potential of early and more accurate detection of pathogens. However, this technique has not been well validated for BSI diagnosis in patients with hematological disease. Therefore, we designed a prospective multicenter study to compare the diagnosis performance in BSI.
Study Type
OBSERVATIONAL
Enrollment
300
peripheral 4ml for mNGS detection
Yuqian Sun
Beijing, China
RECRUITINGdiagnosis performance
the sensitivity and specificity of mNGS
Time frame: 14 days after sapmpling
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