Taurine as a Possible Anti-aging Therapy?

University of Sao Paulo24 enrolled

Overview

Among the strategies that can improve the body's ability to counteract oxidative stress, the use of nutritional antioxidants has been investigated. Taurine is a "semi-essential" amino acid, also called a nitrogen compound, which has been used as an effective antioxidant due to its ability to neutralize hypochlorous acid, an extremely toxic oxidant produced by leukocytes in the inflammatory process in humans.

Objective: To evaluate the oxidative parameters of women aged 55 to 70 years after 16 weeks of taurine supplementation. Methods: Twenty-four women age 55 to 70 will be randomly assigned to two groups: control group (GC), supplemented with placebo (1.5 g of starch); and taurine group (GTAU), supplemented with taurine (1.5 g), for 16 weeks. Anthropometry, functional capacity test, taurine, and levels of oxidative stress markers will be determined in pre and post intervention plasma samples. Food consumption will be assessed before, during, and after the intervention. The results will be analyzed by an ANOVA two-way repeated measures mixed model, with the Sidak post hoc (p \< 0.05).

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Oxidative Stress

Interventions

TaurineDIETARY_SUPPLEMENT

Taurine supplementation in capsules of 500 grams of taurine powder, total dosage: 1.5 gram/day

PlaceboDIETARY_SUPPLEMENT

Placebo supplementation in capsules of 500 grams of starch powder, total dosage: 1.5 gram/day

Eligibility

Sex: FEMALEMin age: 55 YearsMax age: 70 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Had being aged 55-70 years; * Female; * Post-menopausal; * Sedentary (not practicing physical exercise for at least 6 months). Exclusion Criteria: * Chronic kidney diseases; * Infectious contagious diseases; * Coronary heart disease; * Smokers * Alcoholics.

Locations (1)

Escola de Educação Física e Esporte de Ribeirão Preto

Ribeirão Preto, São Paulo, Brazil

Outcomes

Primary Outcomes

Change from baseline in blood oxidative stress marker measurement - Superoxide Dismutase (SOD).

The superoxide dismutase (SOD) activity in erythrocytes was evaluated by the spectrophotometric method, and were calculated at 16 weeks in comparision to the baseline.

Time frame: sixteen weeks

Change from baseline in blood oxidative stress marker measurement - Glutathione reductase (GR).

Glutathione reductase (GR) activity was determined by the spectrophotometric method at 37 ºC/340nm after the oxidation of NADPH in the presence of oxidized glutathione, and were calculated at 16 weeks in comparision to the baseline.

Time frame: sixteen weeks

Change from baseline in blood oxidative stress marker measurement - Malondialdehyde (MDA).

The malondialdehyde (MDA) were calculated at 16 weeks in comparision to the baseline.

Time frame: sixteen weeks

Data from ClinicalTrials.gov

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