The Breath-2 Trial

Leiden University Medical Center35 enrolled

Overview

This is a randomized, cross over, experimental trial in which carotid body function will be evaluated in 35 healthy subjects during partial muscle relaxation and after recovery from muscle relaxation

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

DOUBLE

Enrollment

Conditions

Peripheral Chemosensitivity

Interventions

Muscle relaxationOTHER

Rocuronium will be used to induce partial paralysis

ReversalOTHER

Sugamamdex will be used to reverse muscle relaxation

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: \* age \> 18 years Exclusion Criteria: * BMI index \> 30 kg/m2 * Known or suspected neuromuscular disorders impairing neuromuscular function; * Allergies to muscle relaxants, anesthetics or narcotics; * A (family) history of malignant hyperthermia or any other muscle disease; * Any neurological or psychiatric illness (including a history of anxiety). * ASA class 3 or higher * Gastro-oesophageal regurgitation

Locations (1)

Leiden Medical University

Leiden, South Holland, Netherlands