* Cancer is the second leading cause of death after cerebrovascular strokes and is a significant obstacle to each nation's future growth. * Worldwide, Breast cancer is the most common cancer in women and the 5th leading cause of cancer related deaths that comes after lung cancer, colorectal cancer, liver cancer and gastric cancer. * More than half of all breast cancer cases in the world occur in developing countries. Egypt has a high mortality rate from breast cancer, with a rate of 21.3 per 100,000 cases. Breast cancer is diagnosed at an advanced stage in 60 to 70% of cases in Egypt. The median age at diagnosis in Egypt is 48.5 years, which seems to be a decade younger than in Europe and North America.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
100
Patients will receive 40 Gy in 15 fractions to the entire breast and or chest wall over the course of 3 weeks.
Patients will receive 26 Gy in 5 fractions to the entire breast and or chest wall over the course of one week.
Sohag University Hospital
Sohag, Egypt
RECRUITINGAcute toxicity
Rate of acute grade 2 toxicity or higher from the treatment till 3 months (NCI\_CTCAE). Each patient will be assesed weekly during radiotherapy and monthly for 3 months post radiotherapy.
Time frame: 3 months
Chronic toxicity
Rate of chronic toxicity grade 2 or higher ( NCI\_CTCAE) from 6 months after radiotherapy up to 2 years. Each patient will be assessed before treatment and at 6,12 and 24 months from treatment.
Time frame: 6 months post treatment up to 2 years
Local recurrence
Rate of ipsilateral locoregional tumor recurrence proved by imaging and biopsy.
Time frame: Up to 2 years
Patient compliance
Compliance to treatment (number of interrupted days of radiotherapy.
Time frame: From the starting point of treatment till the end of treatment ( 3 weeks in control arm and 1 week in experimental arm
Overall survival
Overall survival (Number of the surviving patients for 2 years in each arm of the study)
Time frame: From time of diagnosis up to 2 years post radiotherapy
Mohamed S gaber, professor
CONTACT
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