Forceps Biopsy Versus Cryo-biopsy in the Diagnosis of Lung Cancer

Nashwa Ahmed Mohammad amin30 enrolled

Overview

This study was comprised of 30 patients who were scheduled for a diagnostic bronchoscopy due to a suspicion of lung cancer in order to obtain tissue samples for a final diagnosis , four biopsies were taken by each of cryobiopsy and forceps biopsy , to evaluate and compare the diagnostic yield of endobronchial cryobiopsy and forceps biopsy in the diagnosis of lung cancer .

Diagnostic bronchoscopic interventions are used to evaluate and tissue sample from endobronchial lesions utilising variety of devices that can be delivered through the operative channel of a fibrio-optic bronchoscope. All of the procedures were carried out with 2% lidocaine instillation and midazolam IV sedation All patients signed a written informed consent form for bronchoscopy and tissue sampling with forceps and a cryoprobe.between August 2020 and June 2021. All interventions were performed in the bronchoscopy unit of the Chest Medicine Department at Benha university Data were collected, revised, coded and entered to the Statistical Package for Social Science (IBM SPSS) version 23. The quantitative data with parametric distribution were presented as mean, standard deviations and ranges.

Study Type

INTERVENTIONAL

Allocation

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Lung Cancer

Interventions

bronchoscpePROCEDURE

bronchoscopic biopsy from lung mass using cryobiopsy and forceps

Eligibility

Sex: ALLMin age: 47 YearsMax age: 88 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * severe uncorrected hypoxemia despite supplemental oxygen treatment * unstable angina * uncontrolled arrhythmias, * severe hypercarbia, * unstable cervical spine. * Coagulopathy that cannot be reversed * Chronic obstructive pulmonary disease (COPD) exacerbation * Severe Illness * old age * malnutrition * Patient who refused to have a bronchoscopy performed Exclusion Criteria: Patients' histories, including age, sex, and smoking status, were documented for all participants in the trial Clinical examination and medical history Complete blood count, serum creatinine, liver enzymes, INR, bleeding time, and clotting time are all routine laboratory tests Plain chest X-ray and chest computed tomography were used in the radiological workup\* Arterial blood gas on room air. bronchoscopy and biopsy taking with forceps and cryobiopsy \-

Locations (1)

Benha University Hospital- Chest Department

Cairo, Egypt

Outcomes

Primary Outcomes

Comparative study between Endobronchial Forceps-Biopsy and Cryo-Biopsy in the Diagnosis of bronchogenic carcinoma

The comparison between groups regarding qualitative data was done by using Chi-square test and/or Fisher exact test when the expected count in any cell found less than 5.at week 40

Time frame: comprative , week 40

Data from ClinicalTrials.gov

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