Study on Tolerability and Pharmacokinetics of TQB2858 Injection in Subjects With Advanced Malignant Tumors

Inclusion Criteria: * Phase I (dose-escalation phase). a) Patients with advanced malignant solid/hematologic tumors who have a histologically and/or cytologically confirmed diagnosis and who have failed standard therapy or lack effective therapies. * Phase II (cohort expansion phase). 1. Unresectable, recurrent or metastatic adenoid soft tissue sarcoma diagnosed by histology. 2. Previously received anti-vascular targeted drug therapy 3. Have at least one measurable lesion Response Evaluation Criteria in Solid Tumors (RECIST 1.1). * Age: 18 to 70 years old; * The Eastern Cooperative Oncology Group (ECOG) score: 0 to 1; * The expected survival period is ≥3 months; * Normal function of major organs * Women of childbearing age should agree to use effective contraceptive measures during the study period and 6 months after the end of the study, and have a negative serum or urine pregnancy test within 7 days before enrollment in the study; men should agree to use effective contraception during the study period and after the end of the study period 6 Effective contraceptive measures must be used within one month. * Patients voluntarily enroll in this study, sign an informed consent form and comply well. Exclusion Criteria: * Combined diseases and medical history: 1. Have presented with or currently have concurrent other malignancies within 2 years. 2. Unresolved toxic reactions due to any prior treatment above Common Terminology Criteria for Adverse Events(CTCAE) grade 1, excluding alopecia, peripheral sensory nerve disorders. 3. Major surgical treatment or significant traumatic injury within 28 days prior to the start of study treatment. 4. Long-term untreated wounds or fractures. 5. An arterial/venous thrombotic event within 6 months, such as cerebrovascular accident, deep vein thrombosis and pulmonary embolism. 6. Persons with a history of psychotropic substance abuse who are unable to abstain or have a mental disorder. 7. Subjects with any severe and/or uncontrollable disease, including: * Tumor-related symptoms and treatment: 1. Have received surgery, chemotherapy, radiotherapy or other anti-cancer therapy within 4 weeks prior to the start of study treatment. 2. Treatment with proprietary Chinese medicines with clear antitumor indications in the National Medical Products Administration (NMPA)-approved drug formulary within 2 weeks prior to the start of study treatment. 3. Prior receipt of immune dual anti-treatment drugs against the same target of TQB2858 injection. 4. Uncontrolled pleural effusions, pericardial effusions, or ascites that still require repeated drainage (in the judgment of the investigator); 5. Brain metastases with less than 4 weeks of stable symptom control after discontinuation of dehydrating agents and steroids. * Research and treatment related: 1. History of live attenuated vaccination within 28 days prior to the start of study treatment. 2. Prior history of severe allergy to macromolecular drugs or allergy to known components of TQB2858 injection. 3. Active autoimmune disease requiring systemic therapy that occurred within 2 years prior to the start of study treatment. 4. Diagnosis of immunodeficiency or being treated with systemic glucocorticoids or any other form of immunosuppressive therapy. * Participation in other clinical trials of antineoplastic drugs within 4 weeks prior to enrollment. * Subjects who, in the judgment of the investigator, have a concomitant illness that seriously jeopardizes the safety of the subject or interferes with the completion of the study, or for whom other reasons are deemed to exist for ineligibility for enrollment.