Serotoninergic activity in brain structures involved in food control and avoidance, such as the basal ganglia, is poorly understood in Anorexia Nervosa.
A simultaneous positron emission tomography (PET)- functional magnetic resonance imaging (fMRI) approach and testing of food preferences and choices will provide further insight into the link between potential abnormalities in serotoninergic transmission and the specific food restriction disorder for Anorexia Nervosa. These Data can pave the way for new therapeutic avenues.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
57
Subjects will be asked to complete a food choice task in PET/MRI. During the task, PET and MRI scans will be acquired simultaneously. This will allow us to see in real time during food choices the brain activations of the subjects. For imaging we will inject the DASB tracer intravenously. This radio ligand is a tracer that allows us to see the cerebral serotoninergic transmission by positron emission tomography.
The second technique used is the eye tracker that will allow us to analyze food avoidance behaviors through the eyes. With a "TOBII" eye tracker we wil be able to follow the gaze of the subjects during the food preference task. It is a non-invasive approach.
CHU de Saint-Etienne
Saint-Etienne, France
difference between the two groups of the study for serotonin binding potential
The difference in serotonin binding potential is measured by PET scan of the brain networks between anorexic and control subjects.
Time frame: Day 2
correlation between abnormalities in serotonin binding potential and abnormalities in brain activity in resting state
serotonin binding potential is measured with \[11C\]DASB PET. abnormalities in brain activity is measured on fMRI. correlation between abnormalities in serotonin binding potential and abnormalities in brain activity is quantified by change in the resting state
Time frame: Day 2
correlation between abnormalities in serotonin binding potential and abnormalities in brain activity during the food choice tasks.
serotonin binding potential is measured with \[11C\]DASB PET. abnormalities in brain activity is measured on fMRI. correlation between abnormalities in serotonin binding potential and abnormalities in brain activity is quantified by change during the food choice tasks.
Time frame: Day 2
correlation between anxiety profile and brain activity
brain activity is measured on fMRI and anxiety is measured by the score STAI YB. STAI YB \> 51 = Moderate to high anxiety STAI YB\<51 = Low anxiety
Time frame: Day 2
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