This study compares the efficacy and safety of direct mechanical thrombectomy versus bridging therapy in patients with anterior circulation large vessel occlusion in a cohort of patients treated at the stroke unit of a single centre at Alexandria University in Egypt.
This study compares the efficacy and safety of direct mechanical thrombectomy versus bridging therapy in patients with anterior circulation large vessel occlusion in a cohort of patients treated at the stroke unit of a single centre at Alexandria University in Egypt. In the first arm, 17 patients were recruited and underwent direct mechanical thrombectomy without receiving recombinant tissue plasminogen activator. In the bridging therapy arm, 34 patients received first tissue plasminogen activator then underwent direct mechanical thrombectomy. The efficacy was evaluated by the NIHSS improvement 24 hours following stroke onset and the modified Rankin scale 3 months following stroke. Safety was assessed by the procedural complications rate especially the hemorhagic transformation.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
51
FDA approved devices for stent retrieval during mechanical thrombectomy
FDA approved devices for stent aspiration during mechanical thrombectomy
FDA approved drug for treatment of acute ischemic stroke within 4.5 hours of strokeonset
Alexandria University Faculty of Medicine
Alexandria, Egypt
Modified Rankin Scale score
A measurement of functional independence following ischemic stroke
Time frame: 3 months
Complication rate
The rate and type of complications occuring postoperatively
Time frame: within one week postoperatively
The National Institutes of Health Stroke Scale (NIHSS) score
A validated scale for assessment of neurological dysfunction associated with stroke
Time frame: at 24 hours postoperatively
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