Tongzhou Cohort Study

Beijing Friendship Hospital31,080 enrolled

Overview

Long-term Impact of Overweight/Obesity and Hypertension on Cardiovascular Risk in Middle-aged and Elderly Adults

Overweight and obesity are major risk factors associated with the development of hypertension, poor blood pressure control, and adverse cardiovascular outcomes. However, evidence regarding the long-term impact of overweight/obesity and hypertension on cardiovascular risk in middle-aged and elderly populations remains limited. Therefore, the present study aims to evaluate the long-term effects of overweight/obesity and hypertension on cardiovascular risk in middle-aged and elderly adults.Additionally, a subgroup analysis will be conducted in participants with sarcopenia to assess the influence of blood pressure on prognosis, exploring potential interactions between muscle loss, hypertension, and cardiovascular outcomes.

Study Type

OBSERVATIONAL

Enrollment

31,080

Conditions

Obesity Hypertension

Interventions

No interventionOTHER

This is an observational study without any intervention

Eligibility

Sex: ALLMin age: 45 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Ages of ≥ 45 years * Participants from routine health examinations at Tongzhou Community Health Service Center * Availability for follow-up until 2026 * No major barriers to provide written consent Exclusion Criteria: * NA

Locations (1)

Beijing Friendship Hospital, Capital Medical University

Beijing, Beijing Municipality, China

Outcomes

Primary Outcomes

Percentage of participants with major adverse cardiovascular events (MACEs)

Percentage of participants with major adverse cardiovascular events (MACEs), including all-cause death, nonfatal myocardial infarction (MI), nonfatal stroke and coronary revascularization.

Time frame: 2021-2026

Secondary Outcomes

Percentage of participants with all-cause death

Percentage of participants with cardiovascular, non-cardiovascular and undetermined death.

Time frame: 2021-2026

Percentage of participants with MI

Percentage of participants with fatal and nonfatal MI.

Time frame: 2021-2026

Percentage of participants with stroke

Percentage of participants with fatal and nonfatal stroke.

Time frame: 2021-2026

Percentage of participants undergoing coronary revascularization

Percentage of participants undergoing ischemia- and non-ischemia-driven coronary revascularization.

Time frame: 2021-2026

Change in BP control rate

Change in BP control rate (office BP: SBP \< 140 mmHg and DBP \< 90 mmHg) from baseline to follow-up.

Time frame: 2021-2026

Change in SBP

Change in SBP from baseline to follow-up.

Time frame: 2021-2026

Change in estimated glomerular filtration rate (eGFR)

Data from ClinicalTrials.gov

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