The objective of this study is to determine the efficacy of seven different formulations currently marketed and commercially available cosmetic products on skin tone evenness, post-inflammatory hyperpigmentation, and discrete pigmentation in females of Fitzpatrick skin types IV-VI.
This is a single site, double-blind randomized, split face, efficacy study. All subjects will receive a cleanser, Day Cream/sunscreen, and two treatment products. The treatment products will be applied in a split face fashion including behind the ear. Local volunteer subjects will be enrolled such that a total of eighty-four (84) subjects will complete the study; with 24 subjects completing in each treatment. Each subject will receive a cleanser, Day Cream/sunscreen and two treatment products as per the randomization. Subjects will use the cleanser twice daily, Day Cream/sunscreen in the morning, and the treatment products as specified after cleansing in the evening, for a period of 16 weeks. Clinical assessments, non-invasive instrument measurements and photographs will be completed at baseline and weeks 4, 8, 12, and 16. Biopsies will be taken at baseline and Week 16.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
84
Topical emulsions containing anti-aging ingredients
Skin Tone Unevenness
Using a 0-9 scale where 0= even tone and 9=severe blotchy hyperpigmentation. Subjects will be recruited with mild to moderate skin tone unevenness. The goal is to show improvements by dermatologist assessments and photography
Time frame: Every 4 weeks up to 16 weeks
Skin Firming
Using a non-invasive clinical instrument (Cutometer) skin elasticity will be measure of the facial cheek
Time frame: Every 4 weeks up to 16 weeks
Skin Moisture
Using a non-invasive clinical instrument (SkiCon) skin conductance will be measure of the facial cheek
Time frame: Every 4 weeks up to 16 weeks
Skin Oiliness
Using a non-invasive clinical instrument (Sebumeter) skin conductance will be measure of the facial cheek
Time frame: Every 4 weeks up to 16 weeks
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