A Phase 1b Study of ONL1204 Ophthalmic Solution in Patients with Progressing Open Angle Glaucoma

Inclusion Criteria: 1. Males and females aged ≥18 years old 2. Able and willing to give informed consent and attend study visits 3. Controlled intraocular pressure (IOP) (≤21 mmHg) in both eyes for all previous 3 visits before Screening and at Screening in both eyes 4. Prior to screening, 3 or more Humphrey Visual Field (HVF) tests (with acceptable reliability standards) or 3 or more Optical Coherence Tomography (OCT) studies of the study eye on record 5. Open angle glaucoma that is progressing in the study eye 6. HVF 24-2 at Screening with acceptable reliability standards and MD scores Exclusion Criteria: Considerations for either eye 1. Best Corrected Visual Acuity (BCVA) at Screening of ≤64 letters (Snellen equivalent of worse than 20/50) 2. Severe open angle glaucoma 3. Glaucoma due to non-open angle causes 4. Worse than mild non-proliferative diabetic retinopathy Considerations for study eye: 5. Visual field results suggestive of another disease (eg, altitudinal field defect) 6. Evidence of macular edema based on OCT imaging and Investigator's judgement 7. Previous intravitreal (IVT) injections, history of retinal surgery, history of retinal laser 8. Cataract surgery within 3 months of Screening or yttrium-aluminum-garnet capsulotomy (YAG) within 4 weeks of Screening 9. Anticipated need for surgical or procedural intervention for glaucoma, cataract, posterior capsular opacity, refractive error, or retinal conditions during the study Other general exclusion criteria: 10. The requirement for oral carbonic anhydrase inhibitors to control intraocular pressure 11. Severe, unstable, or uncontrolled cardiovascular, diabetic, renal, or pulmonary disease, based on Investigator's judgement 12. Systolic blood pressure \>180 mmHg or diastolic blood pressure \>110 mmHg 13. Women who are pregnant, breastfeeding, or contemplating pregnancy during the study period and men who are contemplating contributing sperm for a biologic child during the study period 14. Participation in other ophthalmic clinical trials or use of any other investigational drugs or devices in either eye or systemically for 3 months before Screening (Visit 1)