Evaluation of variation of mineral density and bone microarchitecture after allogeneic HSCTs transplant in hematologic malignancies. Comparison with the general population.
Allo-HSCTs performed for the treatment of hematologic malignancies has been increasing in recent years. There is therefore a growing interest in the quality of life of these patients and in particular for the bone complications of the transplant. Indeed, it was found a high incidence of osteoporosis / osteopenia in this population associated with an increased risk of osteoporotic fracture from 6 to 9 times compared to the general population. This study will evaluate the variation of mineral density and bone microarchitecture parameters by bone densitometry with measurement of trabecular bone score and fracturing risk before and after allogeneic HSCTs transplant, at predefined times. It's also evaluating pain scale, fracture incidence and bone remodeling markers.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
OTHER
Masking
NONE
Enrollment
120
Evaluation of bone osteodensitometry
Chu Amiens
Amiens, France
CHU CAEN
Caen, France
Chu Lille
Lille, France
Chu Rouen
Rouen, France
bone mineral density evaluation
bone mineral density evaluation post-transplant
Time frame: change over time between diagnostic, transplant, 6 months and 12 months post-transplant
bone mineral density evaluation
long term bone mineral density evaluation
Time frame: change over time between 24 months and 36 months post-transplant
Bone architectural abnormalities and fracture risk
evaluation of bone architectural abnormalities and fracture risk
Time frame: change over time between diagnostic, transplant, 6 months and 12 months post-transplant
bone remodeling markers
Dosage of bone remodeling markers
Time frame: change over time between diagnostic, transplant, 6 months and 12 months post-transplant
Pain evaluation
Pain evaluation (EVA)
Time frame: change over time between diagnostic, transplant, 6 months, 12 months, 24 months and 36 months post-transplant
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