Phase 2/3 Study of TLC590 for Postsurgical Pain Management

Inclusion Criteria: * Male or female at least 18 years old * BMI 18-39 kg/m2 * Scheduled to undergo a primary, unilateral Lichtenstein inguinal hernia repair with mesh * ASA Physical Status Classification of 1, 2 or 3 Exclusion Criteria: * Clinically significant abnormal clinical laboratory test value * Clinically significant 12-lead ECG * History of orthostatic hypotension or syncope * History of significant renal, hepatic, gastrointestinal, cardiovascular, metabolic, neurologic, psychiatric, or other condition * History of seizure or currently taking anticonvulsants * History of hypersensitivity to bupivacaine/ropivacaine, any other amide-type local anesthetic, propofol, oxycodone or morphine (or other opioids) * History of severe or refractory post-operative nausea or vomiting (PONV) * Abnormalities of laboratory parameters: HbA1c, platelet, hemoglobin, WBC, serun bilirubin/alanine aminotransferase/aspartate aminotrasferase, serum creatinine, PTT/INR * Concurrent acute, or chronic painful restrictive/physical condition * Received opioid therapy for longer than 4 days per week * Prohibited medication: aspirin and other anti-platelet medication, anticoagulants, class III antiarrhythmic drugs, strong CYP1A2 inhibitors,systemic corticosteroids, NSAID, opioid, bupivacaine or ropivacaine, any investigational product * History of drug abuse or alcohol abuse * Positive results on the urine drug screen or alcohol breath test * History of HIV; active HBV or HCV * An inguinal hernia repair in the last 3 months or has undergone 3 or more surgeries within 12 months * Malignancy in the last 2 years * Documented sleep apnea or on home continuous positive airway pressure treatment (CPAP) * Personal or family history of malignant hyperthermia.