The Comparison of Hemodynamic Effects Between Remimazolam-remifentanil and Propofol-remifentanil in Patients Undergoing Laparoscopic Cholecystectomy

Yonsei University274 enrolled

Overview

This study is conducted to determine whether the occurrence of hypotension is reduced by the combined use of remimazolam and remifentanil compared to the conventional combination use of propofol and remifentanil. Patients enrolled in the study are infused continuously with either propofol or remimazolam from the start of anesthesia to the end of surgery.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

274

Conditions

Acute Cholecystitis

Interventions

propofol groupDRUG

During induction, the propofol group starts the effect site concentration at 4.0 ng/ml with TCI and adjusts it to around 3.0 \~ 4.0 ng/ml after intubation to maintain an appropriate EEG-based depth of anesthesia.

remimazolam groupDRUG

In the remimazolam group, start remimazolam at 6 mg/kg/hr and adjust it to 1 mg/kg/hr after loss of consciousness to maintain an appropriate EEG-based depth of anesthesia.

Eligibility

Sex: ALLMin age: 19 YearsMax age: 90 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1. patients 19 years of age or older 2. the American Society of Anesthesiologists classification 1-3 3. patients undergoing laparoscopic cholecystectomy at Severance Hospital Exclusion Criteria: 1. Emergency surgery, 2. patients with heart disease or arrhythmias, 3. patients undergoing concurrent surgery other than laparoscopic cholecystectomy, 4. obesity (BMI\>30), 5. patients who were admitted on the surgery day, 6. foreigners, 7. illiteracy

Locations (1)

Yonsei University Health System, Severance Hospital

Seoul, South Korea